Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model

Nanomedicine : Nanotechnology, Biology, and Medicine
Kaikai HuYan-Qing Guan

Abstract

Parkinson's disease (PD) is second most common neurodegenerative disorder worldwide. Although drugs and surgery can relieve the symptoms of PD, these therapies are incapable of fundamentally treating the disease. For PD patients, over-expression of α-synuclein (SNCA) leads to the death of dopaminergic neurons. This process can be prevented by suppressing SNCA over-expression through RNA interference. Here, we successfully synthesized gold nanoparticles (GNP) composites (CTS@GNP-pDNA-NGF) via the combination of electrostatic adsorption and photochemical immobilization, which could load plasmid DNA (pDNA) and target specific cell types. GNP was transfected into cells via endocytosis to inhibiting the apoptosis of PC12 cells and dopaminergic neurons. Simultaneously, GNP composites are also used in PD models in vivo, and it can successfully cross the blood-brain barrier by contents of GNP in the mice brain. In general, all the works demonstrated that GNP composites have good therapeutic effects for PD models in vitro and in vivo.

Citations

Apr 14, 2019·The Journal of Gene Medicine·Shanshan Wang, Rongqin Huang
Sep 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alice BalfourierFlorence Gazeau
Mar 8, 2019·Nanomaterials·Daniel Mihai TeleanuRaluca Ioana Teleanu
Dec 1, 2018·Nano Convergence·You Jung KangHansang Cho
Jan 9, 2019·Frontiers in Neuroanatomy·Natalia López-González Del ReyJavier Blesa
Nov 4, 2020·Journal of Neurology·Jonathan BaskinSimon J G Lewis
Dec 16, 2020·Emerging Topics in Life Sciences·Parasuraman PadmanabhanBalázs Gulyás
Feb 23, 2021·Colloids and Surfaces. B, Biointerfaces·Matheus Scarpatto RodriguesJade de Oliveira
Aug 28, 2021·International Journal of Molecular Sciences·Keelan Jagaran, Moganavelli Singh
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ilyas OzcicekAsel Aydeger
Sep 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thuy Trang NguyenGiau Van Vo

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