Neuroprotective effect of L-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats

Neuroscience Letters
Z BiniendaLarry Schmued

Abstract

A plant and fungal toxin, 3-NPA, acts as an inhibitor of mitochondrial function via irreversible inactivation of the mitochondrial inner membrane enzyme, succinate dehydrogenase (SDH). Inhibition of SDH disturbs electron transport and leads to cellular energy deficits and neuronal injury. We have shown that pretreatment with l-carnitine, while not significantly attenuating SDH inhibition, prevented hypothermia and oxidative stress-associated increased activity of free radical-scavenging enzymes. Here, a neurohistological method was applied to examine the effect of carnitine pretreatment against 3-NPA-induced neurotoxicity. Twenty adult male Sprague-Dawley rats were randomly divided into two groups (n = 10/group). Rats in the first group were injected twice with 3-NPA at 30 mg/kg s.c., 2 days apart, and the second group of animals received l-carnitine pretreatment at 100 mg/kg 30-40 min before 3-NPA administration. Rats in both groups were perfused 7 days later and their brains harvested. Degenerating neurons were identified and localized via the fluorescent marker Fluoro-Jade B. In the three animals that survived 3-NPA dosing, one exhibited no pathology, one exhibited moderate unilateral damage to the striatum, and the third ex...Continue Reading

References

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Citations

Jun 7, 2005·Neurobiology of Disease·Yukitoshi IzumiCharles F Zorumski
Dec 25, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hanaa H Ahmed
Jan 4, 2017·The Journal of Craniofacial Surgery·Kemal Karaca, Fevzi Solmaz
Jan 24, 2007·Physiological Reviews·Guido KroemerCatherine Brenner
Dec 24, 2020·Nutrients·Giulia MalaguarneraMichele Malaguarnera
Nov 3, 2021·Journal of Applied Toxicology : JAT·Hanne Bendiksen SkogvoldKatja Benedikte Prestø Elgstøen

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