Neuroprotective effect of magnesium supplementation on cerebral ischemic diseases.

Life Sciences
Runnan XuJianghui Dong

Abstract

Ischemic encephalopathy is associated with a high mortality and rate of disability. The most common type of ischemic encephalopathy, ischemic stroke, is the second leading cause of death in the world. At present, the main treatment for ischemic stroke is to reopen blocked blood vessels. However, despite revascularization, many patients are not able to achieve good functional results. At the same time, the strict time window (<4.5 h) of thrombolytic therapy limits clinical application. Therefore, it is important to explore effective neuroprotective drugs for the treatment of ischemic stroke. Magnesium is a natural calcium antagonist, which exerts neuroprotective effects through various mechanisms. However, while most basic studies have shown that magnesium supplementation can help treat cerebral ischemia, intravenous magnesium supplementation in large clinical trials has failed to improve prognosis of ischemic patients. Therefore, we review the basic and clinical studies of magnesium supplementation for cerebral ischemia. According to the route of administration, treatment can be divided into intraperitoneal magnesium supplementation, intravenous magnesium supplementation, arterial magnesium supplementation and intracranial magn...Continue Reading

References

Sep 1, 1992·American Journal of Perinatology·G A AisenbreyV Catanzarite
Oct 1, 1992·Archives of Biochemistry and Biophysics·A Romani, A Scarpa
Apr 1, 1990·Stroke; a Journal of Cerebral Circulation·S Hatashita, J T Hoff
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G P SchielkeA L Betz
Apr 1, 1991·Kidney International·A E GrzegorzewskaT W Chen
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y IzumiJ Seylaz
Feb 1, 1990·Stroke; a Journal of Cerebral Circulation·F S SilversteinM V Johnston
Feb 1, 1991·American Journal of Obstetrics and Gynecology·W W ChoiM M Todd
Apr 1, 1989·Stroke; a Journal of Cerebral Circulation·J L BlairM M Todd
Jan 1, 1989·The British Journal of Ophthalmology·W S WilkinsonK A Gitter
Mar 16, 1988·Journal of the National Cancer Institute·R L Dedrick
Jan 1, 1970·Brain : a Journal of Neurology·H DavsonM B Segal
Feb 1, 1971·Journal of Neurochemistry·J TurinskyH A Sloviter
Jul 1, 1984·American Heart Journal·L T Iseri, J H French
Jan 1, 1981·Annual Review of Medicine·R K Rude, F R Singer
Jun 1, 1981·Journal of Neurosurgery·T H JonesR G Ojemann
Jul 1, 1995·Stroke; a Journal of Cerebral Circulation·K W Muir, K R Lees
Jun 1, 1995·Anaesthesia and Intensive Care·J C Lynch, Y Shehabi
Jan 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B T Altura, B M Altura
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A L BetzX D Ren
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·W D DietrichR Busto
Oct 27, 1997·Journal of Neurosurgical Anesthesiology·T Fuchs-BuderE Tassonyi
May 22, 1998·Stroke; a Journal of Cerebral Circulation·K W Muir, K R Lees
Oct 3, 1998·Journal of Neurology·Y LamplI Sarova-Pinhas
Dec 4, 1998·Stroke; a Journal of Cerebral Circulation·S SchwabW Hacke
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F ColbourneA M Buchan
Nov 26, 1999·The Veterinary Clinics of North America. Food Animal Practice·J P Goff
Mar 17, 2000·Neurosurgery·G R SutherlandD J McCarthy
Nov 4, 2000·Journal of Neurotrauma·A LewénP H Chan
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F ColbourneA M Buchan

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Marie-Eva Pickering

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Zeitschrift für Kardiologie
D J Beuckelmann
The Netherlands Journal of Medicine
P J VisserJ B Hoekstra
Journal of Thrombosis and Thrombolysis
L E Rabbani
Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium
M Weiss, B Lasserre
© 2021 Meta ULC. All rights reserved