Neuroprotective effect of nipradilol [3,4-dihydro-8-(2-hydroxy-3-isopropylamino)-propoxy-3-nitroxy-2H-1-benzopyran] in a rat model of optic nerve degeneration

Journal of Glaucoma
Md Zahidul KarimTetsuya Yamamoto

Abstract

Currently, nipradilol, an alpha-1 beta-blocker with a nitric oxide donative action, is used as an ocular hypotensive agent for glaucoma patients in Japan. The aim of the present study was to investigate the neuroprotective effect of nipradilol on optic nerve injury in rats. Using a calibrated cross-action forceps, a crush lesion was inflicted unilaterally on the optic nerve 2 mm behind the globe of adult Wistar albino rats and followed by topical instillation of either 0.25% nipradilol or the vehicle in both eyes twice daily until killing. A sham operation was conducted on the contralateral eye. Intraocular pressure measurement was performed 3 days before and 4, 7, 14, 21, and 28 days after acute injury of the optic nerve. One week before killing, Fluoro-Gold was injected into the bilateral superior colliculi to identify surviving retinal ganglion cells (RGCs). Twenty-eight days after injury, retinal damage was assessed morphologically. There was no significant difference in the intraocular pressure of both eyes between the nipradilol and control groups. Within 1 month, the mean RGC density in the vehicle-treated group had decreased to 71.58+/-0.102% of that of the contralateral eye, whereas the optic nerve crush with topical a...Continue Reading

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Citations

Sep 1, 2015·The Veterinary Clinics of North America. Small Animal Practice·Anthony F AlarioStefano Pizzirani
Aug 19, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shaoqing HeThomas Yorio
Jan 22, 2011·Current Opinion in Ophthalmology·Helen V Danesh-Meyer
Dec 30, 2009·Current Opinion in Neurology·George NtaiosPatrik Michel

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