Neuroprotective effect of pharmacological postconditioning on cerebral ischaemia-reperfusion-induced injury in mice

The Journal of Pharmacy and Pharmacology
Amarjot Kaur GrewalThakur Gurjeet Singh

Abstract

To investigate the mechanism of neuroprotection rendered via pharmacological postconditioning in cerebral ischaemia-reperfusion-induced injury in mice. Pharmacological postconditioning is strategy which either involves hindering deleterious pathway or inducing modest stress level which triggers intracellular defence pathway to sustain more vigorous insult leading to conditioning. Hence, in current research we explored the potentiality of CGS21680 (0.5 mg/kg; i.p), an adenosine A2 A receptor agonist and PTEN inhibitor, SF1670 (3 mg/kg; i.p.) to trigger postconditioning after inducing cerebral global ischaemia (17 min) and reperfusion (24 h)-induced injury via occlusion of both carotid arteries. Mice were also given treatment with LY294002 (1.5 mg/kg; i.p.), a PI3K inhibitor and adenosine A2 A receptor antagonist, Istradefylline (2 mg/kg; i.p.), to establish the precise mechanism of postconditioning. Various biochemical and behavioural parameters were assessed to examine the effect of pharmacological postconditioning. Pharmacological postconditioning induced with CGS21680 and SF1670 attenuated the infarction along with improved behavioural and biochemical parameters in comparison with ischaemia-reperfusion control group. The outc...Continue Reading

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Citations

Jan 19, 2021·The Journal of Pharmacy and Pharmacology·Heena KhanThakur Gurjeet Singh
Mar 18, 2021·Cellular and Molecular Neurobiology·D Pereira-FigueiredoK C Calaza
May 7, 2021·Journal of Molecular Neuroscience : MN·Komal ThapaAmarjot Kaur
Apr 6, 2021·Pharmacological Reports : PR·Heena KhanAmarjot Kaur
Oct 16, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shareen Singh, Thakur Gurjeet Singh

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