PMID: 18202548Jan 19, 2008Paper

Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo

Journal of Pharmacological Sciences
Ju Yeon BanYeon Hee Seong

Abstract

Previous work has shown that the Smilacis chinae rhizome (SCR) markedly inhibits amyloid beta protein (25-35)-induced neuronal cell damage in cultured rat cortical neurons. The present study was conducted to further verify the neuroprotective effect of SCR on excitotoxic and cerebral ischemic injury using both in vitro and in vivo studies. Exposure of cultured cortical neurons to 1 mM N-methyl-D-aspartate (NMDA) for 12 h induced neuronal cell death. SCR (10 and 50 microg/ml) inhibited NMDA-induced neuronal death, elevation of intracellular calcium ([Ca(2+)](i)), and generation of reactive oxygen species (ROS) in primary cultures of rat cortical neurons. In vivo, SCR prevented cerebral ischemic injury induced by 3-h middle cerebral artery occlusion (MCAO) and 24-h reperfusion. The ischemic infarct was significantly reduced in rats that received SCR (30 and 50 mg/kg, orally), with a corresponding improvement in neurological function. Moreover, SCR treatment significantly decreased the histological changes observed following ischemia. Oxyresveratrol and resveratrol isolated from SCR also inhibited NMDA-induced neuronal death, increase in [Ca(2+)](i), and ROS generation in cultured cortical neurons, suggesting that the neuroprotect...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Oct 1, 1995·Trends in Pharmacological Sciences·I Mody, J F MacDonald
Nov 1, 1994·Biochemical Society Transactions·K KatsuraB K Siesjö
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Feb 1, 1994·Current Opinion in Neurology·W D Heiss, R Graf
May 7, 1993·Brain Research·S C Bondy, D K Lee
Feb 1, 1993·Stroke; a Journal of Cerebral Circulation·R J LaingR W Laing
Dec 10, 1998·Journal of Biomedical Science·A Y Sun, Y M Chen
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Jan 5, 2000·Physiological Reviews·D G Nicholls, S L Budd
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Y K GuptaGeeta Chaudhary
Dec 10, 2002·Brain Research·Qun WangAlbert Y Sun
Nov 19, 2003·Gerontology·Egemen SavaskanFranz Müller-Spahn
Oct 16, 2004·The American Journal of Chinese Medicine·Hyun Joo LeeYeon Hee Seong
Jan 25, 2005·Neurochemical Research·Qun WangAlbert Y Sun
Jan 3, 2006·Journal of Ethnopharmacology·Xiao-Shun ShuXiang-Liang Yang
Jan 18, 2006·Acta Pharmacologica Sinica·Li-ping ZhangJuan Zhao

❮ Previous
Next ❯

Citations

Dec 20, 2014·BioMed Research International·Teng MaLan Tan
Oct 23, 2012·Chinese Journal of Integrative Medicine·Qing CaiChun-Shen Li
Oct 19, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Xiao-Qian LiuHsiao-Ming Chao
Feb 2, 2013·Journal of Neural Transmission·Prabhakar OrsuAnnapurna Akula
Nov 5, 2010·Chemical & Pharmaceutical Bulletin·Hong-Yi SunYong Zou
Nov 16, 2013·The American Journal of Chinese Medicine·A-Rang ImMi Young Lee
Nov 5, 2008·Biological & Pharmaceutical Bulletin·Thi Thuy Ha NguyenYeon Hee Seong
Sep 18, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Juan CenBian-Sheng Ji
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Jesús Pérez-HernándezAnahí Chavarría
Jul 23, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Joo Youn KimYeon Hee Seong
Apr 7, 2010·European Journal of Pharmacology·Feng ZhangJing-Shan Shi
Dec 22, 2009·Metabolism: Clinical and Experimental·Daniel H Montes-CortesIvonne M Olivares-Corichi
Jul 28, 2015·Neurochemistry International·Shibu M PouloseBarbara Shukitt-Hale
Apr 11, 2012·European Journal of Pharmacology·John T WeberJennifer E Slemmer
Feb 26, 2015·Pharmacological Reports : PR·Gelareh VahabzadehMassoud Mahmoudian
Jun 27, 2009·Archives of Pharmacal Research·Soon Ock ChoYeon Hee Seong
Sep 9, 2015·Archives of Pharmacal Research·Hong Kyu LeeYeon Hee Seong
May 17, 2012·Acta Crystallographica. Section E, Structure Reports Online·Hui DengXiaopeng Hu
Jan 19, 2021·Frontiers in Pharmacology·Md Habibur RahmanVineet Mittal
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kittisak Likhitwitayawuid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.