Neuroprotective effect of the active components of three Chinese herbs on brain iron load in a mouse model of Alzheimer's disease

Experimental and Therapeutic Medicine
Xian-Hui DongXi-Qing Chai

Abstract

Alzheimer's disease (AD) is a neurodegenerative brain disorder and the most common cause of dementia. New treatments for AD are required due to its increasing prevalence in aging populations. The present study evaluated the effects of the active components of Epimedium, Astragalus and Radix Puerariae on learning and memory impairment, β-amyloid (Aβ) reduction and brain iron load in an APPswe/PS1ΔE9 transgenic mouse model of AD. Increasing evidence indicates that a disturbance of normal iron homeostasis may contribute to the pathology of AD. However, the underlying mechanisms resulting in abnormal iron load in the AD brain remain unclear. It has been hypothesized that the brain iron load is influenced by the deregulation of certain proteins associated with brain iron metabolism, including divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1). The present study investigated the effects of the active components of Epimedium, Astragalus and Radix Puerariae on the expression levels of DMT1 and FPN1. The treatment with the active components reduced cognitive deficits, inhibited Aβ plaque accumulation, reversed Aβ burden and reduced the brain iron load in AD model mice. A significant increase was observed in the levels of DMT1-...Continue Reading

References

Jun 1, 1991·Lancet·D R Crapper McLachlanD F Andrews
Oct 1, 1991·Trends in Pharmacological Sciences·J Hardy, D Allsop
May 1, 1984·Journal of Neuroscience Methods·R Morris
Feb 15, 1993·Archives of Biochemistry and Biophysics·D L MillerK Iqbal
Aug 1, 1997·Nature Genetics·J V Gray, K J Johnson
Aug 1, 1997·Journal of Neuropathology and Experimental Neurology·C I SzeL J Martin
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Apr 5, 2000·The Journal of Biological Chemistry·S Abboud, D J Haile
Apr 5, 2000·The Journal of Biological Chemistry·H KawabataH P Koeffler
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·R E Fleming, W S Sly
Jun 11, 2002·Annual Review of Nutrition·Nathan E Hellman, Jonathan D Gitlin
Jan 28, 2003·Blood Cells, Molecules & Diseases·Gregory J AndersonChristopher D Vulpe
Mar 21, 2003·The Biochemical Journal·Hongyan LiZhong Ming Qian
Aug 2, 2003·Journal of the American Geriatrics Society·Anne E FinefrockP Murali Doraiswamy
Dec 4, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Xudong HuangAshley I Bush
Aug 2, 2005·Cell Metabolism·Adriana DonovanNancy C Andrews
Jan 31, 2006·Neuroimaging Clinics of North America·Bruno P ImbimboNunzio Pomara
Mar 1, 2006·Journal of Structural Biology·Guijian LiuXudong Huang
May 5, 2006·Acta Neurochirurgica. Supplement·S WanG Xi
Aug 1, 2006·Lancet·Kaj BlennowHenrik Zetterberg
Nov 15, 2006·Seminars in Pediatric Neurology·Megan Whitnall, Des R Richardson
Nov 18, 2006·The Biochemical Journal·Bryan MackenzieMatthias A Hediger
Apr 2, 2008·Neurobiology of Aging·Li-Hong ZhangZhan-You Wang
Jul 22, 2008·Brain Research Bulletin·Li-Hong ZhangZhan-You Wang
Aug 6, 2008·Cell Metabolism·Ivana De DomenicoJerry Kaplan
Apr 18, 2009·Stroke; a Journal of Cerebral Circulation·Yuxiang GuGuohua Xi
Jun 2, 2009·Cellular and Molecular Life Sciences : CMLS·Gregory Jon Anderson, Christopher D Vulpe
Feb 16, 2010·Biochemical and Biophysical Research Communications·Ali Shawki, Bryan Mackenzie
Feb 15, 2011·European Journal of Pharmacology·Mei HanJin-Ming Zhang
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaomin LiDennis J Selkoe
Sep 10, 2011·Current Pharmaceutical Design·Klaudia Jomova, Marian Valko
Jul 17, 2012·Neurobiology of Aging·Jiang WuMohamed Naguib
Aug 15, 2012·Journal of Neuroendocrinology·Cassia R OverkElliott J Mufson

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Software Mentioned

SPSS
Image
Pro Plus

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.