Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Shu-Qing ChenXin-Qiang Zheng

Abstract

As the population ages, neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) impose a heavy burden on society and families. The pathogeneses of PD and AD are complex. There are no radical cures for the diseases, and existing therapeutic agents for PD and AD have diverse side effects. Tea contains many bioactive components such as polyphenols, theanine, caffeine, and theaflavins. Some investigations of epidemiology have demonstrated that drinking tea can decrease the risk of PD and AD. Tea polyphenols can lower the morbidity of PD and AD by reducing oxidative stress and regulating signaling pathways and metal chelation. Theanine can inhibit the glutamate receptors and regulate the extracellular concentration of glutamine, presenting neuroprotective effects. Additionally, the neuroprotective mechanisms of caffeine and theaflavins may contribute to the ability to antagonize the adenosine receptor A2AR and the antioxidant properties, respectively. Thus, tea bioactive components might be useful for neuronal degeneration treatment in the future. In the present paper, the neuro protection and the mechanisms of tea and its bioactive components are reviewed. Moreover, the potential challenges and futu...Continue Reading

References

Sep 12, 1997·The Journal of Biological Chemistry·J M MüllerR A Rupec
Feb 1, 2002·Biochemical and Biophysical Research Communications·Jae Hoon BaeDae-Kyu Song
Oct 24, 2002·Neurobiology of Aging·Hagen SchroeterCatherine Rice-Evans
Feb 25, 2003·Bioscience, Biotechnology, and Biochemistry·Takami KakudaHitoshi Niino
Apr 3, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yona LevitesMoussa B H Youdim
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Mar 17, 2004·Cancer Treatment Reviews·Juan Angel Fresno VaraManuel González-Barón
Dec 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brad A SutherlandIan Appleton
Feb 14, 2006·The American Journal of Clinical Nutrition·Shinichi KuriyamaIchiro Tsuji
Jul 6, 2006·The European Journal of Neuroscience·Jennifer M HorwoodSabrina Davis
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Jan 30, 2007·Journal of Agricultural and Food Chemistry·Lei-Chwen LinTung-Hu Tsai
Jun 8, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alessia PascaleFiorenzo Battaini
Nov 17, 2007·Biological Psychology·Crystal F HaskellAndrew B Scholey
Feb 23, 2008·Journal of Neuroscience Research·Takami KakudaYukio Yoneda
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
Apr 25, 2008·Parkinsonism & Related Disorders·Boris KandinovAmos D Korczyn
Jan 6, 2009·Biological & Pharmaceutical Bulletin·Miao HeFu-Jun Chen
Jan 23, 2009·Journal of Alzheimer's Disease : JAD·Marjo H EskelinenMiia Kivipelto
Aug 1, 2009·Nature Reviews. Drug Discovery·Pixu LiuJean J Zhao
Sep 29, 2009·Neurochemistry International·Hélio Vitoriano NobreGlauce Socorro de Barros Viana
Jan 19, 2010·Biochimica Et Biophysica Acta·Eun Kyung Kim, Eui-Ju Choi

❮ Previous
Next ❯

Citations

Mar 11, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Vahideh OveissiMohammad Hosein Farzaei
Dec 8, 2019·Neurotoxicity Research·Hsiang-Chien TsengCheng-Chia Tsai
May 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monira PervinYoriyuki Nakamura
Aug 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karla Martinez PomierGiuseppe Melacini
Aug 8, 2020·Frontiers in Aging Neuroscience·Xiaoji CuiYing Liang
Jun 6, 2019·Nutrients·Patricia Alonso-AndrésJosé Luis Albasanz
Oct 24, 2018·Pharmaceuticals·Marco T Nuñez, Pedro Chana-Cuevas
Jun 22, 2018·Neural Regeneration Research·Aline FreyssinAgnès Rioux Bilan
Nov 28, 2019·Journal of the International Society of Sports Nutrition·Javier ZaragozaLem Taylor
May 26, 2020·Mechanisms of Ageing and Development·Alexander VaisermanOleh Lushchak
Aug 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Muhammad AdnanZeliha Selamoglu
May 27, 2021·Journal of Agricultural and Food Chemistry·Hanieh NargehHamidreza Pazoki-Toroudi
Jun 3, 2021·International Journal of Molecular Sciences·Thayza Martins MelzerPatricia S Brocardo
May 31, 2021·Neurochemistry International·Charles Elias AssmannIvana Beatrice Mânica da Cruz
Jun 23, 2021·ACS Chemical Neuroscience·Patricia AlonsoMairena Martín
Aug 11, 2021·Bioorganic & Medicinal Chemistry Letters·Baskar SelvarajJae Wook Lee
Aug 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Swati HalderAbhijit Dey
Sep 24, 2021·Reproductive Biology and Endocrinology : RB&E·Vahid MalekiMohammad Alizadeh
Jul 4, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Rishi Kant SinghArbind Acharya

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Related Papers

Oxidative Medicine and Cellular Longevity
Abdelkader BasliTristan Richard
Advances in Experimental Medicine and Biology
Mario Caruana, Neville Vassallo
© 2022 Meta ULC. All rights reserved