Neuroprotective effects of a Rhodiola crenulata extract on amyloid-β peptides (Aβ1-42 ) -induced cognitive deficits in rat models of Alzheimer's disease

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Xiaoxue ZhangFei Han

Abstract

Rhodiola crenulata has been wildly used as a healthy food, antidepressant and antifatigue for many years in China. Recent studies suggested that Rhodiola crenulata extract (RCE) has cognitive protective effects in the treatment of Alzheimer's disease (AD). To assess the protective effects of RCE on cognitive deficits and clarify its therapeutic mechanisms in Aβ1-42 -induced rat models of AD. RCE was prepared by freeze-drying technology. Their protective effects on Aβ1-42-induced rat models of AD and the preliminary therapeutic mechanisms were studied. The Y maze test and Morris water maze (MWM) test were conducted to evaluate the learning and memory abilities of the rats. Subsequently, biochemical assays, hematoxylin-eosin staining, immunohistochemistry and Western blotting were performed to elucidate the mechanisms. RCE significantly increased the spontaneous alternation (F (6, 111) = 8.165, p < 0.001), prolonged the swimming time (F (6, 111) = 20.143, p < 0.001) and decreased the escape latency in rat models of AD. In addition, RCE significantly increased the acetylcholine (Ach) level and the choline acetyl transferase (ChAT) activity (F (6, 34) = 6.033, p < 0.001; F (6, 34) = 6.958, p < 0.001, respectively), repaired the dam...Continue Reading

Citations

Sep 26, 2020·Frontiers in Behavioral Neuroscience·Leticia R DarePâmela B Mello-Carpes
Jan 24, 2020·Current Neuropharmacology·Hareram BirlaSandeep Kumar Singh
Oct 7, 2021·Critical Reviews in Food Science and Nutrition·Zhijun YangHui-Lian Zhu

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