Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer's disease

Journal of Neuroinflammation
Minsook YeHyunsu Bae

Abstract

Alzheimer's disease (AD) is a severe neuroinflammatory disease. CD4(+)Foxp3(+) regulatory T cells (Tregs) modulate various inflammatory diseases via suppressing Th cell activation. There are increasing evidences that Tregs have beneficial roles in neurodegenerative diseases. Previously, we found the population of Treg cells was significantly increased by bee venom phospholipase A2 (bvPLA2) treatment in vivo and in vitro. To examine the effects of bvPLA2 on AD, bvPLA2 was administered to 3xTg-AD mice, mouse model of Alzheimer's disease. The levels of amyloid beta (Aβ) deposits in the hippocampus, glucose metabolism in the brain, microglia activation, and CD4(+) T cell infiltration were analyzed to evaluate the neuroprotective effect of bvPLA2. bvPLA2 treatment significantly enhanced the cognitive function of the 3xTg-AD mice and increased glucose metabolism, as assessed with 18F-2 fluoro-2-deoxy-D-glucose ([F-18] FDG) positron emission tomography (PET). The levels of Aβ deposits in the hippocampus were dramatically decreased by bvPLA2 treatment. This neuroprotective effect of bvPLA2 was associated with microglial deactivation and reduction in CD4(+) T cell infiltration. Interestingly, the neuroprotective effects of bvPLA2 were a...Continue Reading

References

Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E A DennisY A Hannun
Jul 28, 1972·Science·E Habermann
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jul 5, 1994·Biochemical Pharmacology·A B MukherjeeN Pattabiraman
Jan 8, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A Nordberg, A L Svensson
Jun 5, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·F MuehlhauserK Fassbender
Aug 22, 2001·Lancet·A CagninR B Banati
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca S McHugh, Ethan M Shevach
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edith G McGeer, Patrick L McGeer
Dec 4, 2003·Neurobiology of Aging·Salvatore OddoFrank M LaFerla
Aug 6, 2004·Nature·Mark P Mattson
Aug 6, 2005·Progress in Neurobiology·Michelle L Block, Jau-Shyong Hong
Oct 26, 2005·Neuromolecular Medicine·Terrence TownMike Mullan
Nov 2, 2005·Neurotoxicity Research·I KadiuM P Thomas
Dec 2, 2005·Synapse·Martine M MirrioneStella E Tsirka
Apr 28, 2006·Nature Reviews. Immunology·Howard L Weiner, Dan Frenkel
May 12, 2006·Neurological Research·Sylvia Delgado, William A Sheremata
Jun 9, 2006·European Journal of Immunology·Francescopaolo GranataMassimo Triggiani
Oct 24, 2006·Neuroscience and Biobehavioral Reviews·L Giménez-LlortA Fernández-Teruel
Jan 4, 2007·The Journal of Experimental Medicine·Katharina LahlTim Sparwasser
Feb 3, 2007·Chemistry and Physics of Lipids·Lars LinderothThomas L Andresen
Aug 7, 2007·Journal of Leukocyte Biology·Ashley D ReynoldsR Lee Mosley
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malabendu JanaKalipada Pahan
Feb 19, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Qinan BaoArion F Chatziioannou
Jun 6, 2009·Journal of Alzheimer's Disease : JAD·Anis LarbiTamas Fulop
Jul 21, 2009·The American Journal of Geriatric Pharmacotherapy·Marwan N Sabbagh
Oct 23, 2009·Alzheimer's Research & Therapy·Susan D RountreeRachelle S Doody
Jan 14, 2010·Neuromolecular Medicine·Reisa A SperlingKeith A Johnson
Mar 23, 2010·Cell·Christopher K GlassFred H Gage
Sep 18, 2010·Journal of Alzheimer's Disease : JAD·Sandhya SubramanianHalina Offner
Sep 23, 2010·Journal of Alzheimer's Disease : JAD·Verena H Finder
Oct 12, 2010·Biomedical and Environmental Sciences : BES·Ling WangJie Li
Nov 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heekyung LeeHyunsu Bae
Oct 22, 2011·Expert Review of Neurotherapeutics·Stella Karantzoulis, James E Galvin
Mar 1, 2012·Frontiers in Pharmacology·Egle Solito, Magdalena Sastre

❮ Previous
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Citations

Dec 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Md Sakib HossenMd Ibrahim Khalil
Jan 21, 2017·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali KomiRicardo D Zwiener
May 15, 2018·Frontiers in Cellular Neuroscience·Helena Solleiro-Villavicencio, Selva Rivas-Arancibia
Oct 2, 2019·Frontiers in Immunology·Frances L EvansDenise C Fitzgerald
Jun 7, 2020·Molecular Neurodegeneration·Jatin MachhiHoward E Gendelman
Mar 13, 2018·Frontiers in Pharmacology·Jessica M de SouzaFabiola M Ribeiro
May 16, 2019·Neural Regeneration Research·Baruh PolisAbraham O Samson
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rim WehbeZiad Fajloun
Jan 30, 2020·Frontiers in Immunology·Yan-Mei HuangHai-Lu Zhao
Oct 1, 2020·Toxins·Ting-Yen Lin, Ching-Liang Hsieh
Mar 27, 2018·Journal of Neuroimmunology·Tomomi KiyotaHoward E Gendelman
May 22, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Isabela F L MotaMárcia R Mortari
Jun 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ehsan H Abu-ZeidShereen El Abdel-Hamid

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Methods Mentioned

BETA
flow cytometry
FACS

Software Mentioned

CellQuest Pro
Prism
Statistical Parametric Mapping

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