Neuroprotective effects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons

Neurotoxicology
Hao SongLi-Hua Yao

Abstract

In Alzheimer's disease (AD), β-amyloid (Aβ) protein toxicity increases the formation of reactive oxygen species (ROS) and intracellular calcium levels, resulting in neuronal dysfunction, neurodegenerative disorders, and cell death. Cordycepin is a derivative of the nucleoside adenosine; also, it is speculated to exert neuroprotective effects against Aβ-induced oxidative toxicity in hippocampal neurons. In the present study, the fluorescence detection method and whole-cell patch-clamp recordings were used to study the neuroprotective effects against Aβ-induced toxicity in the primary hippocampal cultured neurons. The results revealed that Aβ25-35 toxicity causes increased cellular ROS production and abnormal calcium homeostasis in hippocampal neurons. Moreover, Aβ25-35-induced cytotoxicity led to a series of downstream events, including the activation of acetylcholinesterase, increased p-Tau expression, and increased apoptosis. Cordycepin inhibits ROS production, elevated levels of Ca2+ induced by Aβ25-35, and the activation of acetylcholinesterase; all these are involved in oxidative-induced apoptosis. In addition, it decreases the increased p-Tau expression that plays a key role in the initiation of the AD. Results showed that...Continue Reading

Citations

May 17, 2019·Food Science and Biotechnology·Mei Tong HeEun Ju Cho
Nov 5, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Li-Hua YaoLi-Ping Huang
May 28, 2019·Current Medicinal Chemistry·Ze WangJing-Shan Shi
Jul 24, 2021·European Journal of Pharmacology·Anusha GovindulaJayesh Mudgal
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Ying ChenRong-Jane Chen
Oct 12, 2021·Journal of Agricultural and Food Chemistry·Jiaming LiuJing Sun
Nov 3, 2021·Aging Cell·Linbin Dai, Yong Shen
Apr 13, 2019·European Journal of Pharmacology·Zhong-Si-Wei DongChu-Hua Li

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