Neuroprotective effects of curcumin against rats with focal cerebral ischemia-reperfusion injury

International Journal of Molecular Medicine
Lu XuYan Huang

Abstract

The aim of the present study was to investigate the protective effects of curcumin and its effect on the methyl ethyl ketone/extracellular signal regulated kinase/cAMP‑response element binding protein (MEK/ERK/CREB) pathway. The study was conducted in vivo and in vitro as follows: In vivo: Focal cerebral ischemia‑reperfusion (IR) models of rats were made with the plug‑line method. Adult male Sprague‑Dawley rats were divided into four groups: Sham operation control group, IR and curcumin‑treatment groups (100 mg/kg and IC, 300 mg/kg). The effects of curcumin on neurological deficit scores, brain water content and infarct volumes were identified. Transmission electron microscope was utilized to observe morphological changes of hippocampal neurons; hematoxylin and eosin staining was used to observe morphological changes of brain tissue; and the terminal deoxynucleotidyl transferase (TdT)‑mediated dUTP nick end labeling method detected neurons apoptosis of hippocampal CA1. Finally, western blot analysis detected the expression of phosphorylated (p)‑MEK, p‑ERK, p‑CREB, B‑cell lymphoma‑2 (Bcl‑2) and Bcl‑2 associated X protein (Bax). In vitro: An oxygen‑glucose deprivation/reoxygenation method was used on primary cultured astrocytes t...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
Oct 3, 1999·Physiological Reviews·P Lipton
Dec 14, 1999·Learning & Memory·J C SelcherJ D Sweatt
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A M BrambrinkO Kempski
Jun 30, 2001·Trends in Pharmacological Sciences·M J Marinissen, J S Gutkind
Jul 11, 2001·Biochemical and Biophysical Research Communications·M J BoucherN Rivard
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Mar 22, 2002·Neuron·Edwin J Weeber, J David Sweatt
Jun 12, 2002·Biochemical and Biophysical Research Communications·Zhongjian JiangAlbert Cheung Hoi Yu
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Rainer Fogelholm
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Taku SugawaraPak H Chan
Aug 27, 2005·Stroke; a Journal of Cerebral Circulation·Barbara BatesUNKNOWN Department of Veterans Affairs
Dec 6, 2007·Surgical Neurology·James Grotta, John Marler
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Jeyaraj Durai PandianJagaralpudi M K Murthy
Jul 31, 2010·Neuron·Michael A MoskowitzCostantino Iadecola
Nov 4, 2010·Journal of Neurochemistry·Kensuke SakamotoKarl Obrietan
May 28, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marjan AjamiHamidreza Pazoki-Toroudi
Oct 31, 2012·International Journal of Molecular Sciences·Jens MinnerupChristoph Kleinschnitz
Jan 5, 2014·European Journal of Pharmacology·Marta GazalManuella P Kaster
Jan 31, 2014·Neurologia Medico-chirurgica·Kyoung-Tae KimYounghoon Jeon
Oct 7, 2016·In Vitro Cellular & Developmental Biology. Animal·Bin ZhouXiaolei Zhang
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

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