Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

Neural Regeneration Research
Adem Bozkurt ArasMurat Cosar

Abstract

Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis.

References

May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Oct 1, 1994·Clinical Biochemistry·B Stavric
May 1, 1994·The British Journal of Surgery·P A Grace
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
Apr 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R HataK A Hossmann
Apr 14, 1999·Cell Death and Differentiation·A G Porter, R U Jänicke
Jan 20, 2000·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S IşlekelN Ozdamar
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P H Chan
Jun 23, 2004·Lancet Neurology·Ruth BonitaFrank Yatsu
Feb 21, 2006·The European Journal of Neuroscience·María C BurgueteEnrique Alborch
Mar 4, 2006·Journal of Pharmaceutical and Biomedical Analysis·J MatheyC Bennetau-Pelissero
May 25, 2007·Pharmacology, Biochemistry, and Behavior·Aysan Durukan, Turgut Tatlisumak
Aug 7, 2008·Nutritional Neuroscience·Murat CosarOguz Aslan Ozen
Nov 4, 2008·Neuroscience·D A Schreihofer, L Redmond
May 13, 2009·Molecular and Cellular Endocrinology·Christopher R Cederroth, Serge Nef
May 19, 2009·Clinical Neurology and Neurosurgery·R Brouns, P P De Deyn

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Citations

Jul 15, 2015·Archives of Virology·D F ArgentaC M O Simões
May 19, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Lidia CicconeElisabetta Orlandini
Jun 29, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Savita KhannaCameron Rink
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Seyed Zachariah MoradiMohammad Abdollahi
Jan 5, 2021·Critical Reviews in Food Science and Nutrition·Seyed Zachariah MoradiJianbo Xiao
Apr 15, 2020·Experimental Neurology·Epiphani C SimmonsRick G Schnellmann
May 20, 2021·Oxidative Medicine and Cellular Longevity·Hui XuMingfu Wang
May 16, 2021·International Journal of Biological Macromolecules·Ankita R RaneSinjan Choudhary

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Methods Mentioned

BETA
MDA
ELISA

Software Mentioned

SPSS

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