Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

Reviews in the Neurosciences
Chenhui JiChristian Hölscher

Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is a member of the incretin hormones and growth factors. Neurons express the GIP receptor, and GIP and its agonists can pass through the blood brain barrier and show remarkable neuroprotective effects by protecting synapse function and numbers, promoting neuronal proliferation, reducing amyloid plaques in the cortex and reducing the chronic inflammation response of the nervous system. Long-acting analogues of GIP that are protease resistant had been developed as a treatment for type 2 diabetes. It has been found that such GIP analogues show good protective effects in animal models of Alzheimer's disease. Novel dual agonist peptides that activate the GIP receptor and another incretin receptor, glucagon-like peptide -1 (GLP-1), are under development that show superior effects in diabetic patients compared to single GLP-1 agonists. The dual agonists also show great promise in treating neurodegenerative disorders, and there are currently several clinical trials ongoing, testing GLP-1 mimetics in people with Alzheimer's or Parkinson's disease.

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Citations

Jun 16, 2018·Endocrine Reviews·Megan E CapozziJonathan E Campbell
Aug 18, 2016·American Journal of Physiology. Endocrinology and Metabolism·Paul B HigginsFranco Folli
Oct 18, 2019·Current Drug Delivery·Di ZhangYueze Liu
Mar 17, 2020·Expert Opinion on Investigational Drugs·Christian Hölscher
Jul 24, 2020·The Cochrane Database of Systematic Reviews·Caroline A MulvaneyHedley Ca Emsley
Jun 9, 2016·Reviews in the Neurosciences·Yanwei LiChristian Hölscher
Oct 19, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·V A Gault
May 10, 2019·Frontiers in Aging Neuroscience·Christian Hölscher
Jul 20, 2019·Therapeutic Advances in Chronic Disease·Olusola F OnoviranMukaila A Raji
Apr 18, 2017·Immunity & Ageing : I & a·William GalbavyMario J Rebecchi
Apr 13, 2021·Frontiers in Neuroendocrinology·Carmen M LabandeiraAna I Rodriguez-Perez
May 23, 2021·Metabolic Brain Disease·Sherry A FergusonSumit Sarkar
Apr 27, 2021·British Journal of Pharmacology·Christian Hölscher

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Methods Mentioned

BETA
transgenic

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