Abstract
Neonatal hypoxic-ischemic brain damage (HIBD) is a brain disease that is caused by perinatal asphyxia. Icariin (ICA), which is an active component of Epimedii (a Chinese medicinal herb), has been verified to demonstrate a wide range of therapeutic effects, such as alleviating various kinds of brain injury. The current study aims to examine the neuroprotective effects of ICA on neonatal HIBD in mice. A modified version of the Rice-Vannucci method was performed to establish neonatal HIBD in 7-day-old mouse pups that were pretreated with ICA or vehicle. The infarct volume was measured, and behavioral tests were conducted to assess the protective effects of ICA on the neonatal brain and to evaluate functional recovery after injury. TUNEL staining was used to detect cell apoptosis, and the levels of cleaved caspase-3 and phosphorylated protein kinase B (Akt) were determined by using Western blot. We showed that pretreatment with ICA could significantly reduce brain damage, improve neurobehavioral outcomes, and suppress apoptotic cell death following HI injury. ICA reversed the HI-induced reduction in phosphorylated Akt and activation of cleaved caspase-3. The results demonstrate that ICA exerts potential neuroprotective effects on n...Continue Reading
References
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Feb 21, 1997·Neuroscience Letters·R S SidhuM R Del Bigio
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·C ManabatZ S Vexler
Feb 20, 2007·Molecular Neurobiology·Heng ZhaoGary K Steinberg
Apr 10, 2008·Phytotherapy Research : PTR·Ming ZhengYijia Lou
Mar 24, 2009·European Journal of Pharmacology·Lin WangYun Xu
Jul 4, 2009·Journal of Child Neurology·Henrik Hagberg Xiaoyang Wang
Apr 13, 2010·Neuropharmacology·Hai-rong ZhuYun Xu
Jun 4, 2010·European Journal of Pharmacology·Chang-Qing XuJing-Cheng Dong
Mar 16, 2011·The Journal of Pharmacy and Pharmacology·Yao-Hong SongZhi-Ming Zhao
Nov 26, 2011·Biological Trace Element Research·Haibo YangBin Xu
Jan 8, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hasan KilicdagSuzan Zorludemir
Feb 12, 2014·The International Journal of Neuropsychopharmacology·Feng JinJing-Shan Shi
Dec 30, 2014·Marine Drugs·Ai-Jiao XiaoHong-Shuo Sun
Mar 13, 2015·Molecular Brain·Wenliang ChenHong-Shuo Sun
Mar 21, 2015·Neuroscience·B LiuJ Dong
Apr 23, 2015·Asian Pacific Journal of Tropical Medicine·Xue-Mei LiuAi-Min Li
Nov 1, 2016·Molecular Neurobiology·Baofeng XuHong-Shuo Sun
Dec 19, 2015·International Immunopharmacology·Deqing XiongQihai Gong
Aug 16, 2016·Clinics in Perinatology·Ryan M McAdams, Sandra E Juul
Aug 16, 2016·Clinics in Perinatology·Athina Pappas, Steven J Korzeniewski
Feb 14, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wen-Fang ChenMan-Sau Wong
Aug 31, 2018·Molecular Brain·Jie-Min JiaWoo-Ping Ge
Oct 22, 2018·European Journal of Pharmacology·Jie JinZhuo Chen
Citations
Apr 4, 2021·International Journal of Molecular Sciences·Marta Reyes-CorralPatricia Ybot-González
May 13, 2021·Metabolic Brain Disease·Mingming DaiHang Yu
Aug 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sajad FakhriJianbo Xiao