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Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs

Neurotoxicology

Mar 1, 2012

Ying Cindy WangMadhusoodana P Nambiar

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Abstract

The chemical warfare nerve agent, soman irreversibly inhibits acetylcholinesterase (AChE) leading to hypercholinergy and seizures which trigger glutamate toxicity and status epilepticus ultimately resulting in neuropathology and neurobehavioral deficits. The standard emergency treatment...read more

Mentioned in this Paper

Salicylhydroxamic acid
Sedatives
Toxic Encephalitis
Acetylcholine Measurement
BCHE gene
Imidazenil
Entire Dentate Gyrus
Pyridostigmine Bromide
Diazepam
Tremor
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  • Citations1
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Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs

Neurotoxicology

Mar 1, 2012

Ying Cindy WangMadhusoodana P Nambiar

PMID: 22245390

DOI: 10.1016/j.neuro.2011.12.018

Abstract

The chemical warfare nerve agent, soman irreversibly inhibits acetylcholinesterase (AChE) leading to hypercholinergy and seizures which trigger glutamate toxicity and status epilepticus ultimately resulting in neuropathology and neurobehavioral deficits. The standard emergency treatment...read more

Mentioned in this Paper

Salicylhydroxamic acid
Sedatives
Toxic Encephalitis
Acetylcholine Measurement
BCHE gene

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References35
  • Citations1
1234

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