Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma.

Investigative Ophthalmology & Visual Science
Thomas V JohnsonKeith R Martin

Abstract

Purpose. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part by neurotrophic factor secretion. The present study was conducted to determine whether local or systemic bone marrow-derived mesenchymal stem cell (MSC) transplantation can confer neuroprotection in a rat model of laser-induced ocular hypertensive glaucoma. Methods. MSCs were isolated from the bone marrow of adult wild-type and transgenic rats that ubiquitously express green fluorescent protein. MSCs were transplanted intravitreally 1 week before, or intravenously on the day of, ocular hypertension induction by laser photocoagulation of the trabecular meshwork. Ocular MSC localization and integration were determined by immunohistochemistry. Optic nerve damage was quantified by counting axons within optic nerve cross-sections 4 weeks after laser treatment. Results. After intravitreal transplantation, MSCs survived for at least 5 weeks. Cells were found mainly in the vitreous cavity, though a small proportion of discrete cells migrated into the host retina. Intravitreal MSC transplantation resulted ...Continue Reading

Citations

Sep 21, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·David D Eveleth
May 12, 2012·British Medical Bulletin·J M Ong, L da Cruz
Sep 3, 2010·The Journal of Clinical Investigation·Bao Jian Fan, Janey L Wiggs
Dec 31, 2011·Stem Cell Research & Therapy·Rubens Camargo Siqueira
Apr 3, 2012·Zoological Research·Li-Yun GuoZheng-Bo Wang
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Rubens Camargo Siqueira
Nov 21, 2012·Regenerative Medicine·Huasong GaoJianhong Zhu
Mar 13, 2014·International Journal of Molecular Sciences·Bo YuXiaorong Li
Dec 1, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Carol A Rasmussen, Paul L Kaufman
May 1, 2013·The Journal of Biological Chemistry·Heung Sun KwonStanislav I Tomarev
Feb 23, 2012·Cell and Tissue Research·Christian W SchmeerStefan Isenmann
Jan 30, 2013·Cell and Tissue Research·Arthur J Weber
Mar 21, 2013·Cell and Tissue Research·Heike Diekmann, Dietmar Fischer
May 30, 2014·International Journal of Molecular Sciences·Yuanfeng JiangXiaorong Li
Feb 11, 2016·International Journal of Molecular Sciences·Shin-Ichiro OhnoMasahiko Kuroda
Dec 18, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Honghua YuDong Feng Chen
Mar 11, 2015·Stem Cell Research·Ben MeadBen A Scheven
Apr 17, 2012·Experimental Neurology·Natalie D BullRobert J Casson
Feb 22, 2012·Ophthalmology·Elma E Chang, Jeffrey L Goldberg
Feb 3, 2015·Veterinary Ophthalmology·Chan Yun KimYoungje Sung
Aug 6, 2010·Experimental Eye Research·Thomas V JohnsonKeith R Martin
Jul 23, 2015·Neural Regeneration Research·Jeffrey N WeissAlexis Malkin
Apr 17, 2015·Neural Regeneration Research·Ben Mead, Ben A Scheven
Aug 27, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nafiseh Nafissi, Marianna Foldvari
Jul 29, 2015·Journal français d'ophtalmologie·C RoubeixC Baudouin
Dec 10, 2015·Stem Cells International·Louise A Mesentier-LouroMarcelo F Santiago

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Biochemical and Biophysical Research Communications
Saiyuu YuNagahisa Yoshimura
Investigative Ophthalmology & Visual Science
Thomas V JohnsonKeith R Martin
Progress in Brain Research
Natalie D BullKeith R Martin
© 2022 Meta ULC. All rights reserved