Neuroprotective effects of Lepidium meyenii (Maca)

Annals of the New York Academy of Sciences
Alejandro Pino-FigueroaTimothy J Maher

Abstract

The neuroprotective activity of the plant Lepidium meyenii (Maca) was studied in two experimental models: in vitro and in vivo. Crayfish neurons were pretreated with vehicle or the pentane extract from Maca, subjected to H(2)O(2), and their viability determined microscopically and chemically. A significant concentration-neuroprotective effect relationship was demonstrated. The pentane extract was then administered intravenously to rats prior to and following middle cerebral artery occlusion. While infarct volumes were decreased for the lower dose, higher doses increased infarct volumes compared to controls. These results suggest a potential application of Maca as a neuroprotectant.

References

Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·S T ChenJ D Balentine
Sep 15, 1980·Life Sciences·N S Buckholtz
Sep 8, 2000·Bulletin of Experimental Biology and Medicine·Y V BurovT N Robakidze
Oct 29, 2000·Journal of Agricultural and Food Chemistry·T Herraiz
Jan 5, 2002·Phytochemistry·Ilias MuhammadIkhlas A Khan
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I T Johnson
Aug 10, 2002·Phytochemistry·Mario R TellezWeste Osbrink
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Sonia PiacenteCosimo Pizza
Oct 22, 2002·Physiological Genomics·Satinder S SarangSteven R Gullans
Feb 20, 2003·Phytochemistry·Siegfried E DrewesFatima Khan
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
Aug 23, 2003·Journal of Natural Products·Baoliang CuiQun Yi Zheng
Mar 24, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katerina Valentová, Jitka Ulrichová
Jul 16, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Josef Brinckmann, Ed Smith
Jul 17, 2004·Stroke; a Journal of Cerebral Circulation·Isin Unal-CevikTurgay Dalkara
Aug 3, 2004·Phytotherapy Research : PTR·A López-FandoM E Carretero
Aug 18, 2004·Journal of Molecular Neuroscience : MN·Laura ShaughnessyRam Ramabhadran
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Eng H LoThomas P Jacobs
Jan 22, 2005·Reproductive Biology and Endocrinology : RB&E·Gustavo F GonzalesManuel Gasco
Feb 3, 2005·Asian Journal of Andrology·Eduardo Bustos-ObregonGustavo F Gonzales
Feb 3, 2005·Journal of Agricultural and Food Chemistry·Jianping ZhaoIkhlas A Khan
May 5, 2005·Reproductive Biology and Endocrinology : RB&E·Ana C Ruiz-LunaGustavo F Gonzales
May 26, 2005·Pharmacological Reviews·Brian T Hawkins, Thomas P Davis
Oct 22, 2005·Journal of Ethnopharmacology·P BoganiF Visioli
Dec 1, 2005·Phytochemical Analysis : PCA·Megan M McCollomStefan Gafner
Dec 15, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen LauC Vyvyan Howard
Feb 10, 2006·Journal of Ethnopharmacology·Yongzhong ZhangWenwen Jin
Feb 10, 2006·The New England Journal of Medicine·Gregory J del Zoppo
Mar 3, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Julio RubioGustavo F Gonzales
Mar 11, 2006·Cell Biology and Toxicology·K ValentováV Simánek
Jun 27, 2006·BMC Complementary and Alternative Medicine·Julio RubioGustavo F Gonzales
Oct 5, 2006·Anti-cancer Agents in Medicinal Chemistry·Gustavo F Gonzales, Luis G Valerio
Nov 1, 2006·Biochemical Society Transactions·W-R Schäbitz, M Fisher
Nov 1, 2006·Biochemical Society Transactions·M Papadakis, A M Buchan
Jan 6, 2007·Stroke; a Journal of Cerebral Circulation·Kennedy R Lees, Jesse Dawson
Jan 16, 2007·Brain Research Reviews·Suresh L MehtaRam Raghubir
Jan 30, 2007·Lancet·Ralph L SaccoMitchell S V Elkind

❮ Previous
Next ❯

Citations

Sep 23, 2011·In Vitro Cellular & Developmental Biology. Animal·Lucy E J LeeGuy Smagghe
Jul 16, 2013·Molecular Neurobiology·Haifa AlmukadiAlejandro Pino-Figueroa
Dec 18, 2013·Journal of Ethnopharmacology·Fumiaki UchiyamaMisato Ogata
Jul 27, 2015·Biochimie·Céline CrausteJoseph Vercauteren
Oct 7, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Gustavo F Gonzales
Jul 26, 2011·Toxicology Mechanisms and Methods·Julio RubioGustavo F Gonzales
Dec 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shu-Xiao ChenXiao-Jie Gong
Jun 22, 2018·Molecular Neurobiology·M AlasmariA Pino-Figueroa
Jan 18, 2020·Food & Function·Natália da Silva Leitão PeresFlávia Aparecida Reitz Cardoso
Jun 5, 2021·Chemistry & Biodiversity·Yi-Yan ZouYong-Xian Cheng
Nov 8, 2018·Journal of Agricultural and Food Chemistry·Fawen YinBeiwei Zhu
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ranran ZhangMinghua Qiu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.