PMID: 9528918Apr 7, 1998Paper

Neuroprotective effects of MgSO4 and MgCl2 in closed head injury: a comparative phosphorus NMR study

Journal of Neurotrauma
Deanne L Heath, R Vink

Abstract

Previous studies have shown that free magnesium levels decline after traumatic brain injury and that magnesium salt administration improves posttraumatic outcome. These earlier studies, however, have been limited to models of injury that do not produce a significant degree of diffuse axonal injury and have used either MgSO4 or MgCl2 as the magnesium salt. The present study compares the neuroprotective efficacy of MgSO4 and MgCl2 in a severe model of diffuse axonal injury in rats using phosphorus nuclear magnetic resonance spectroscopy and the rotarod test to monitor effects on metabolism and neurologic outcome, respectively. Both MgSO4 and MgCl2 given as a bolus of 100 micromoles/kg at 30 min after severe, closed head injury significantly improved brain intracellular free magnesium concentration and neurologic outcome. These findings suggest that both salts penetrate the blood-brain barrier after brain trauma, enter injured tissue, and subsequently improve neurologic outcome.

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Citations

Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·R Schmid-ElsaesserH J Reulen
Aug 23, 2007·Journal of Neurotrauma·Martina StipplerKevin A Walter
Dec 24, 2010·British Journal of Pharmacology·Niklas Marklund, Lars Hillered
Feb 28, 2015·The Journal of Craniofacial Surgery·Wen LiYan-Feng Li
Feb 17, 2000·Current Opinion in Neurology·H L Laurer, T K McIntosh
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·P M Lea, A I Faden
Dec 9, 2004·Pediatric Research·Donna Reyes MendezAbbot Laptook
Jan 19, 2012·Brain : a Journal of Neurology·Nicola MarchiDamir Janigro
Oct 18, 2007·Journal of Child Neurology·Osaama H KhanMarc R Del Bigio
Jul 11, 2002·European Journal of Pharmacology·Randall L BarbourBurton M Altura

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