Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease

British Journal of Pharmacology
Orly WeinrebMoussa B H Youdim

Abstract

Alzheimer's disease (AD) is accepted nowadays as a complex neurodegenerative disorder with multifaceted cerebral pathologies, including extracellular deposition of amyloid β peptide-containing plaques, intracellular neurofibrillary tangles, progressive loss of cholinergic neurons, metal dyshomeostasis, mitochondrial dysfunction, neuroinflammation, glutamate excitoxicity, oxidative stress and increased MAO enzyme activity. This may explain why it is currently widely accepted that a more effective therapy for AD would result from the use of multifunctional drugs, which may affect more than one brain target involved in the disease pathology. The current review will discuss the potential benefits of novel multimodal neuroprotective, brain permeable drugs, recently developed by Youdim and collaborators, as a valuable therapeutic approach for AD treatment. The pharmacological and neuroprotective properties of these multitarget-directed ligands, which target MAO enzymes, the cholinergic system, iron accumulation and amyloid β peptide generation/aggregation are described, with a special emphasis on their potential therapeutic value for ageing and AD-associated cognitive functions. This review is conceived as a tribute to the broad neur...Continue Reading

References

Sep 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·R AdolfssonB Winblad
Jun 1, 1988·Annals of Neurology·A M PalmerD M Bowen
Feb 15, 1989·Biochemical Pharmacology·M Strolin Benedetti, P Dostert
May 1, 1986·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
Jul 30, 1982·Science·R T BartusA S Lippa
Jan 1, 1980·Journal of Neural Transmission·C J FowlerB Winblad
Jan 20, 1995·The Journal of Biological Chemistry·G L Wang, G L Semenza
Jan 1, 1993·Journal of Neural Transmission. General Section·A M Palmer, S T DeKosky
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·P T FrancisG K Wilcock
Apr 27, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D C SolanoM Racchi
May 10, 2000·Drugs & Aging·M Dooley, H M Lamb
Jun 23, 2000·Annals of the New York Academy of Sciences·G Cohen
Jul 19, 2000·Biochimica Et Biophysica Acta·M A SmithG Perry
Aug 10, 2000·European Journal of Biochemistry·J B SchulzJ Dichgans
May 5, 2001·Expert Opinion on Pharmacotherapy·A Desai, G Grossberg
Aug 23, 2001·Trends in Molecular Medicine·G L Semenza
Oct 2, 2001·Archives of Medical Research·R B MaccioniL Barbeito
Oct 18, 2001·American Journal of Alzheimer's Disease and Other Dementias·M TsolakiA Kazis
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·O L LopezS T DeKosky
May 3, 2002·Neuroscience Research·Lei YangXue-Jun Zhang
Jun 5, 2002·Current Opinion in Lipidology·Sönke ArltAnatol Kontush
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Yogev-FalachMoussa B H Youdim
Sep 5, 2002·Free Radical Biology & Medicine·Thomas J MontineJason D Morrow
Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Dennis J Selkoe, Dale Schenk
Nov 29, 2002·Journal of Neural Transmission. Supplementum·E Giacobini
Dec 21, 2002·Archives of Neurology·UNKNOWN Parkinson Study Group
Feb 13, 2003·Advances in Experimental Medicine and Biology·Juan C Chavez, Joseph C LaManna
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Yogev-FalachMoussa B H Youdim
Dec 31, 2003·Neurotoxicology·Peter RiedererEdna Grünblatt
Apr 21, 2004·Archives of Neurology·UNKNOWN Parkinson Study Group
Apr 23, 2004·Expert Opinion on Investigational Drugs·Roger Bullock

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Citations

Sep 7, 2016·Frontiers in Neuroscience·Rona R RamsayMassimo Valoti
Mar 6, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zdeněk Fišar
Mar 6, 2017·Progress in Neurobiology·Philippe De DeurwaerdèreGiuseppe Di Giovanni
Jul 11, 2019·The FEBS Journal·Maria Luisa Di PaoloAnna Minarini
May 21, 2020·Nanomedicine·Gregory JonesJonghan Kim
Jul 3, 2020·Journal of Food Biochemistry·Afolabi C AkinmoladunAfolabi A Akindahunsi
Jun 16, 2016·British Journal of Pharmacology·Rona R RamsayGiuseppe Di Giovanni
Sep 17, 2020·Molecular Neurobiology·Md Sahab UddinMohamed M Abdel-Daim
Feb 28, 2019·Frontiers in Neuroscience·Marco Tulio Núñez, Cecilia Hidalgo
Sep 20, 2019·Neural Regeneration Research·Alejandro RomeroEva Ramos
Feb 18, 2020·Frontiers in Neuroscience·Nao Yan, JunJian Zhang
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka Zagórska, Anna Jaromin
Aug 19, 2017·Molecular and Cellular Biochemistry·Karine BertoldiIonara Rodrigues Siqueira

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