Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury

Pharmacology, Biochemistry, and Behavior
John G CsernanskyHongxin Dong

Abstract

Recent clinical studies have suggested that treatment with atypical antipsychotic drugs, such as olanzapine, may slow progressive changes in brain structure in patients with schizophrenia. To investigate the possible neural basis of this effect, we sought to determine whether treatment with olanzapine would inhibit the loss of hippocampal neurons associated with the administration of the excitotoxin, kainic acid, in neonatal rats. At post-natal day 7 (P7), rats were exposed to kainic acid via intracerebroventricular administration. Neuronal loss within the CA2 and CA3 subfields of the hippocampus and neurogenesis within the dentate gyrus of the hippocampus were then assessed at P14 by Fluoro-Jade B and BrdU labeling, respectively. Daily doses of olanzapine (2, 6, or 12 mg/day), haloperidol (1.2 mg/kg), melatonin (10 mg/kg), or saline were administered between P7 and P14. Melatonin is an anti-oxidant drug and was included in this study as a positive control, since it has been observed to have neuroprotective effects in a variety of animal models. The highest dose of olanzapine and melatonin, but not haloperidol, ameliorated the hippocampal neuronal loss triggered by kainic acid administration. However, drug administration did no...Continue Reading

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Citations

Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Halil Ibrahim OnderFatih Mehmet Gokce
Oct 21, 2015·Pharmacological Reports : PR·Ewa RojczykRyszard Wiaderkiewicz
Oct 22, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Martin HýžaTomáš Kašpárek
Oct 17, 2008·Pharmacological Reviews·Jeffrey A LiebermanJohn G Csernansky
Aug 13, 2020·International Journal of Molecular Sciences·Joseph Wai-Hin LeungBenson Wui-Man Lau

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