Abstract
The aim of this study was to investigate the neuroprotective effects of propofol, thiopental, etomidate, and midazolam as anesthetic drugs in fetal rat brain in the ischemia-reperfusion (IR) model. Pregnant rats of day 19 were randomly allocated into eight groups. Fetal brain ischemia was induced by clamping the utero-ovarian artery bilaterally for 30 min and reperfusion was achieved by removing the clamps for 60 min. In the control group, fetal rat brains were obtained immediately after laparotomy. In the sham group, fetal rat brains were obtained 90 min after laparotomy. In the IR group, IR procedure was performed. No treatment was given in the IR group. One milliliter intralipid solution, 40 mg/kg propofol, 3 mg/kg thiopental, 0.1 mg/kg etomidate, and 3 mg/kg midazolam was administered intraperitoneally in the vehicle group, propofol group, thiopental group, etomidate group, and midazolam group, respectively, 20 min before IR procedure. At the end of the reperfusion period, the whole brains of the fetal rats were removed for evaluation of thiobarbituric acid reactive substances and for examination by electron microscopy. According to lipid peroxidation data, all the anesthetic drugs provide neuroprotection; however, ultrastr...Continue Reading
References
May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Aug 15, 1991·Archives of Biochemistry and Biophysics·Y TakeuchiY Watanabe
Sep 1, 1995·Neurosurgery·J GuoH H Batjer
Feb 1, 1995·Journal of Neurosurgery·J GuoH H Batjer
Nov 1, 1994·Toxicology and Applied Pharmacology·T R GreenV M Nelson
Oct 1, 1995·Neurosurgery·J C DrummondL W Reynolds
May 1, 1996·European Journal of Anaesthesiology·B K Siesjö, P Siesjö
Jan 16, 1998·Anesthesia and Analgesia·K NishinaY Niwa
Jul 9, 1998·Experimental Brain Research·T KristiánB K Siesjö
Feb 23, 1999·Acta Anaesthesiologica Scandinavica·H ItoH Uchino
Dec 11, 1999·Acta Anaesthesiologica Scandinavica·J B LesserD M Thys
Mar 17, 2000·Anesthesiology·R AlmaasT Rootwelt
Mar 23, 2001·American Journal of Obstetrics and Gynecology·A NakaiT Araki
Sep 14, 2001·Journal of Pineal Research·A WakatsukiT Fukaya
Mar 22, 2002·Journal of Neurosurgical Anesthesiology·Erkan KaptanogluYamac Taskin
Apr 17, 2002·Neurosurgical Review·Rüçhan ErgünFikret Ergüngör
Jul 18, 2002·Journal of Neurosurgery·Erkan KaptanogluEtem Beskonakli
Nov 26, 2002·Journal of the Society for Gynecologic Investigation·Richard BergerArne Jensen
Jan 9, 2003·Clinics in Perinatology·Jennifer Grow, John D E Barks
Jan 24, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ihsan SolarogluKamer Kilinc
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Arne JensenRichard Berger
Jan 7, 2004·Biology of the Neonate·Ihsan SolarogluKamer Kilinc
Feb 15, 2005·British Journal of Anaesthesia·R SasakiM Yamazaki
Feb 25, 2005·Anesthesia and Analgesia·John C DrummondPiyush M Patel
May 24, 2008·Anesthesia and Analgesia·Cheng Wang, William Slikker
Mar 20, 2009·Journal of Neurosurgical Anesthesiology·Baiping LeiIra S Kass
Sep 15, 2009·Annals of Vascular Surgery·Qijing YuDaiming Duan
Oct 14, 2009·Neurotoxicology·Mary Ellen McCannSulpicio G Soriano
Oct 20, 2010·Journal of Medicinal Food·Nitin Bansal, Milind Parle
Citations
Dec 19, 2012·Neurochemical Research·Xiao-Chun ZhaoJian Wang
Oct 17, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Tumul ChowdhuryJayesh Daya
Dec 7, 2013·Medical Science Monitor Basic Research·Ismail YürekliAli Gürbüz
May 20, 2014·Chemico-biological Interactions·P ÁlvarezR L Castillo
Apr 4, 2014·The New England Journal of Medicine·Niklas NielsenUNKNOWN TTM Trial Steering Group
Jan 21, 2015·Biochemical and Biophysical Research Communications·Naoki YamamotoKazuya Sobue
Nov 26, 2015·Therapeutic Hypothermia and Temperature Management·Stephen A FigueroaMary Kay Bader
Sep 10, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V S Laletin, Y N Bykov
Sep 10, 2014·Journal of Critical Care·Chih-Hao ShenKun-Lun Huang
Apr 4, 2015·Chinese Medical Journal·Yun YuRu-Quan Han
Feb 15, 2014·BioMed Research International·Ahmet Eroglu
Jul 25, 2018·CNS Neuroscience & Therapeutics·Xiao-Mei JiangXiao-Liang Wang
Jul 11, 2014·Experimental and Therapeutic Medicine·Yong-Qing GuoJian-Min Jing
Sep 19, 2019·Journal of Complementary & Integrative Medicine·Fatemeh AminiNasrindokht Zamani
Jan 10, 2020·Future Microbiology·Lívia G do Av SáHélio Vn Júnior
Feb 20, 2015·Anesthesia and Analgesia·Cheng-Hua ZhouYu-Qing Wu
Mar 17, 2016·European Journal of Anaesthesiology·Felix UlbrichNils Schallner
Apr 30, 2017·Experimental and Therapeutic Medicine·Renke LiYan Li
Apr 5, 2014·The New England Journal of Medicine·Jon C Rittenberger, Clifton W Callaway
Nov 18, 2015·Molecular Medicine Reports·Shoushi WangHaichen Chu
May 26, 2016·Molecular Medicine Reports·Yujie WangJun Wang
Aug 7, 2019·Neurochemical Research·Mesut Işık
Jun 10, 2014·Expert Review of Neurotherapeutics·Marco Mula
Nov 16, 2018·International Journal of Molecular Medicine·Hang YuMingming Dai
Jul 20, 2016·International Journal of Molecular Medicine·Hong-Yan GongXiu-Qin Yue
Dec 29, 2020·Frontiers in Cellular Neuroscience·Hao FengBaoyu Ma
May 21, 2020·Brain Research Bulletin·Zhiyin TangHongtao Liu
Mar 9, 2021·Frontiers in Neurology·Sjoukje NutmaJeannette Hofmeijer
Apr 4, 2021·Brain Sciences·Marketa ChvojkovaKarel Vales
Jun 7, 2021·Shock·Zhenqian LvRan Liu