Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Ferhat HarmanErkan Kaptanoglu

Abstract

The aim of this study was to investigate the neuroprotective effects of propofol, thiopental, etomidate, and midazolam as anesthetic drugs in fetal rat brain in the ischemia-reperfusion (IR) model. Pregnant rats of day 19 were randomly allocated into eight groups. Fetal brain ischemia was induced by clamping the utero-ovarian artery bilaterally for 30 min and reperfusion was achieved by removing the clamps for 60 min. In the control group, fetal rat brains were obtained immediately after laparotomy. In the sham group, fetal rat brains were obtained 90 min after laparotomy. In the IR group, IR procedure was performed. No treatment was given in the IR group. One milliliter intralipid solution, 40 mg/kg propofol, 3 mg/kg thiopental, 0.1 mg/kg etomidate, and 3 mg/kg midazolam was administered intraperitoneally in the vehicle group, propofol group, thiopental group, etomidate group, and midazolam group, respectively, 20 min before IR procedure. At the end of the reperfusion period, the whole brains of the fetal rats were removed for evaluation of thiobarbituric acid reactive substances and for examination by electron microscopy. According to lipid peroxidation data, all the anesthetic drugs provide neuroprotection; however, ultrastr...Continue Reading

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Citations

Oct 17, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Tumul ChowdhuryJayesh Daya
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Mar 9, 2021·Frontiers in Neurology·Sjoukje NutmaJeannette Hofmeijer

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