Neuroprotective effects of Rosa damascena extract on learning and memory in a rat model of amyloid-β-induced Alzheimer's disease

Advanced Biomedical Research
Ebrahim EsfandiaryAbolghasem Esmaeili

Abstract

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, which is characterized clinically by serious impairment in memory and cognition. Current medications only slow down the dementia progression and the present treatment one-drug one-target paradigm for anti-AD treatment appears to be clinically unsuccessful. Therefore, alternative therapeutic strategies are urgently needed. With respect to multifunctional and multitargeted characteristics of Rosa damascena via its effective flavonoids, we investigated the effects of R. damascena extract on behavioral functions in a rat model of amyloid-β (A-β)-induced Alzheimer's disease. After preparation of the methanolic extract of the R. damascena, HPLC analysis and toxicity studies, median lethal dose (LD50) and dose levels were determined. For evaluation of baseline training behavioral performance, Morris water maze and passive avoidance tests were used. A-β was injected bilaterally into CA1 area of the hippocampus. Twenty-one days after injection of A-β, the first probe trial of the behavioral tests were used to confirm learning and memory impairment. To examine the potential effects of the extract on behavioral tasks, the second probe trials were performed a...Continue Reading

Citations

Feb 11, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Arman ZargaranAbdolali Mohagheghzadeh
Jul 13, 2019·Experimental Physiology·Marjan ErfaniAva Nasrolahi
Mar 2, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mohammad KarimipourHesam Saghaei Bagheri
Apr 21, 2020·Phytotherapy Research : PTR·Adrian L LoprestiPeter D Drummond
Mar 27, 2020·The Journal of Physiological Sciences : JPS·Ghazaleh OmidiAlireza Komaki
Jun 8, 2017·International Journal of Molecular Sciences·Inés MármolMaría Jesús Rodríguez-Yoldi
Feb 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristina Endres
May 4, 2017·Molecular Neurobiology·Karim A Alkadhi
Jul 12, 2020·Journal of Alzheimer's Disease : JAD·Camila CalfioRicardo B Maccioni
Dec 10, 2019·Neuroscience Letters·Abhishek SinghSarika Singh
May 1, 2021·The Journal of Physiological Sciences : JPS·Seyed Asaad KarimiAlireza Komaki
Apr 22, 2021·CNS & Neurological Disorders Drug Targets·Himanshi Varshney, Yasir Hasan Siddique

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