Neuroprotective effects of selective β-1 adrenoceptor antagonists, landiolol and esmolol, on transient forebrain ischemia in rats; a dose-response study

Brain Research
T GoyagiYoko Masaki

Abstract

Although selective beta-1 adrenoceptor antagonists are known to provide neuroprotective effects after brain ischemia, dose-response relationships of their neuroprotective effects have not been examined. The present study was conducted to evaluate whether the degree of brain protection against transient forebrain ischemia would be influenced by different doses of selective beta-1 adrenoceptor antagonists, esmolol and landiolol, in rats. Adult male S.D. rats received intravenous infusion of saline 0.5 ml/h, esmolol 20, 200, 2,000 μg/kg/min, or landiolol 5, 50, 500 μg/kg/min. Infusion was initiated 30 min prior to ischemia and continued for 24h. Ten-minute forebrain ischemia was induced by hemorrhagic hypotension and occlusion of the bilateral carotid arteries. Neurological and histological examinations were performed. Neurological deficit scores at 1, 4 and 7 days were lower, and the number of intact neurons in CA1 hippocampal region was larger in the rats treated with esmolol and landiolol after ischemia, compared with saline-treated rats (P<0.05), whereas no difference was found among different doses of esmolol and landiolol. These results suggested that selective beta-1 adrenoceptor antagonists improved neurological and histol...Continue Reading

References

Feb 1, 1989·The British Journal of Surgery·R G Douglas, J H Shaw
May 1, 1984·Stroke; a Journal of Cerebral Circulation·J A CapraroJ R Little
May 1, 1982·Stroke; a Journal of Cerebral Circulation·J R LittleN T Stowe
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L KatzR Neumar
Dec 1, 1996·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·F Trudeau, M Milot
Jan 12, 2007·The Journal of Trauma·Bryan A CottonJohn A Morris
Jan 12, 2007·The Journal of Trauma·Saman ArbabiWendy L Wahl
Nov 17, 2007·Journal of Anesthesia·Saori Kimura-KurosawaAkiyoshi Namiki
Mar 1, 2008·Journal of the American College of Surgeons·Kenji InabaDemetrios Demetriades
Oct 3, 2008·Neurosurgical Focus·Timothy Y TranJohn W German
Oct 13, 2010·The Journal of Trauma·Thomas J SchroeppelMartin A Croce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.