Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injury

Journal of Neurotrauma
V A Movsesyan, A L Faden

Abstract

The effects of group II mGluR activation by selective agonist (-)-2-oxa-4-aminobicyclo[3.1. 0]hexane-4,6-dicarboxylate (LY379268) were examined in a mouse model of controlled cortical impact (CCI)-induced brain injury and in primary neuronal/glial and neuronal cultures subjected to mechanical trauma. Systemic administration of LY379268 to mice at 30 min after CCI significantly improved both motor and cognitive recovery as compared with vehicle-treated control animals. LY379268 also significantly reduced cell death induced by mechanical injury in rat neuronal/glial and neuronal cultures, as measured by lactate dehydrogenase (LDH) release assay. The neuroprotective effect of LY379268 in vitro was abolished by co-administration of the mGluR2/3 antagonist (s)-alpha-ethylglutamic acid (EGLU); however, co-application of selective mGluR3 antagonist beta-N-acetyl-aspartyl-glutamate (NAAG) had no significant influence in the same system. Together, these findings demonstrate the neuroprotective activity of group II mGluR activation and underscore the role of the mGluR2 subtype for this effect.

References

Jun 5, 1992·European Journal of Pharmacology·C ChiamuleraA Reggiani
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J P PinS F Heinemann
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J Y KohC W Cotman
Jan 10, 1990·European Journal of Pharmacology·A I FadenL J Noble
Jan 1, 1990·Journal of Neurotrauma·Y ShapiraE Shohami
Jan 1, 1990·Annals of Neurology·S S PanterA I Faden
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonU Ungerstedt
Sep 1, 1989·Biological Psychiatry·J W Olney
Jun 1, 1988·Annals of Neurology·A I Faden, R P Simon
Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
Jan 1, 1993·Trends in Pharmacological Sciences·D D Schoepp, P J Conn
Jul 30, 1993·Biochemical and Biophysical Research Communications·R MinakamiH Sugiyama
Sep 1, 1994·Trends in Pharmacological Sciences·J Watkins, G Collingridge
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Feb 25, 1998·Journal of Neurotrauma·A I FadenA G Mukhin
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
May 21, 1999·The European Journal of Neuroscience·F FerragutiC Corti
Oct 26, 1999·Neuropharmacology·D D SchoeppJ A Monn

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Citations

Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kimberly R ByrnesAlan I Faden
Apr 29, 2009·Journal of Neurotrauma·Yung Chia ChenDavid F Meaney
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yongfu WangAndrei B Belousov
May 3, 2011·Annual Review of Biomedical Engineering·Barclay MorrisonMartin L Yarmush
Jun 5, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·David J LoaneAlan I Faden
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Kevin N HascupErin R Hascup
Mar 17, 2018·Neuroscience and Biobehavioral Reviews·Laura B TuckerJoseph T McCabe

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.