Neuroprotective effects of silibinin: an in silico and in vitro study

The International Journal of Neuroscience
Valencia FernandesVinod Tiwari

Abstract

Astrogliosis is a key contributor for many neurological disorders involving apoptosis, neuroinflammation and subsequent neuronal death. Silibinin, a polyphenol isolated from milk thistle (Silybum marianum), has been shown to suppress the astrocyte activation in various neurodegenerative disorders and also exhibit a neuroprotective role in neuroinflammation-driven oxidative damage. The present study was designed with an aim to investigate the neuroprotective effects of Silibinin against LPS induced oxido-inflammatory cascade and astrocyte activation. We have used in-silico molecular modelling techniques to study the interaction and binding affinity of silibinin with chemokine receptors associated with neuroinflammation. We have also tested silibinin against LPS induced oxido-inflammatory cascade and astrocyte activation in C6 glia cell lines. In the present study, we found that treatment with silibinin significantly attenuates LPS-oxidative-nitrosative stress in C6 astrocytoma cells. We also observed the significant inhibition of induced astrocyte activity after treatment with silibinin. Moreover, molecular modelling studies have proposed a binding pose of silibinin with binding sites of p38 MAPK, CX3CR1 and P2X4 which is an imp...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 3, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H P KimV A Ziboh
Nov 18, 2000·American Journal of Physiology. Cell Physiology·E CastigliV Bocchini
Jul 5, 2002·Journal of Molecular Biology·Matthew P JacobsonBarry Honig
Mar 19, 2004·Journal of Medicinal Chemistry·Richard A FriesnerPeter S Shenkin
Mar 19, 2004·Journal of Medicinal Chemistry·Thomas A HalgrenJay L Banks
Jun 22, 2006·Journal of Neurochemistry·Lasse K BakHelle S Waagepetersen
Mar 27, 2007·Chemical Biology & Drug Design·Tom Halgren
Feb 12, 2008·Brain Research·Chris J FeeneyLinda R Mills
May 13, 2009·Journal of Chemical Information and Modeling·Thomas A Halgren
May 27, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yassine ChtourouNajiba Zeghal
Apr 28, 2011·Central Nervous System Agents in Medicinal Chemistry·George BarretoRona G Giffard
Jul 20, 2011·The International Journal of Developmental Biology·Stefan LiebnerHartwig Wolburg
Oct 6, 2011·Neuroscience Letters·Giuseppina MarrazzoGiovanni Li Volti
Feb 14, 2012·The Journal of Pain : Official Journal of the American Pain Society·Lorenzo Di Cesare MannelliCarla Ghelardini
Jun 29, 2012·Immune Network·Mithilesh Kumar JhaKyoungho Suk
Aug 1, 2012·Neurochemical Research·Supriya SwarnkarChandishwar Nath
Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam D BachstetterLinda J Van Eldik
Apr 13, 2013·Journal of Computer-aided Molecular Design·G Madhavi SastryWoody Sherman
Jun 25, 2013·Pain·Ru-Rong JiMaiken Nedergaard
Nov 6, 2013·Frontiers in Cellular Neuroscience·Makoto TsudaKazuhide Inoue
May 14, 2014·Neuroscience and Biobehavioral Reviews·Vinod TiwariSrinivasa N Raja
May 23, 2014·Frontiers in Cellular Neuroscience·Anna K Clark, Marzia Malcangio
Jun 21, 2014·Nature Reviews. Drug Discovery·Ru-Rong JiYong-Jing Gao
Jun 27, 2015·Environmental Toxicology and Pharmacology·Poonam GoswamiSarika Singh
Oct 11, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shreya ThakkarManju Misra

❮ Previous
Next ❯

Citations

Jun 13, 2020·Frontiers in Neuroscience·B KuraszkiewiczM de Carvalho
May 1, 2021·International Journal of Molecular Sciences·Mootaz M SalmanRichard Wade-Martins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Related Papers

Alternative Medicine Review : a Journal of Clinical Therapeutic
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
J Pepping
© 2022 Meta ULC. All rights reserved