Neuroprotective effects of tamoxifen on experimental spinal cord injury in rats

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Ozgür IsmailoğluNecdet Demir

Abstract

The aim of this study was to evaluate the effects of tamoxifen on tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) levels and ultrastructural changes in rats with spinal cord injury. Rats were divided into four groups: control group (laminectomy only), trauma group (laminectomy+spinal trauma), tamoxifen group (laminectomy+spinal trauma+tamoxifen), and vehicle group (laminectomy+spinal trauma+vehicle). Spinal cords were extirpated at the T(7)-T(12) level and tissue samples from the spinal cords were gathered for TNF-alpha and IL-1beta measurements at 1 and 6hours. Spinal cords harvested at 6 hours were evaluated for ultrastructural changes. TNF-alpha and IL-1beta levels at 6 hours were significantly lower in the tamoxifen group than in the trauma group. Electron microscopic examination of tissue from the trauma group revealed gross cell deformities with widespread edema of all structures as well as severe edema in the neuropil. At 6 hours after trauma, these ultrastructural changes were less marked in the tamoxifen group. Our findings support a neuroprotective and restorative role for tamoxifen in the context of secondary pathological biochemical events after SCI.

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Citations

Apr 25, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhengwei LiHuaqiu Zhang
Sep 6, 2013·Journal of Neurotrauma·Jutatip GuptarakOlivera Nesic
Dec 12, 2012·The American Journal of the Medical Sciences·Özgür IsmailoğluNecdet Demir
Mar 24, 2016·Journal of Veterinary Medicine·Braniff de la Torre ValdovinosSergio Horacio Duenas Jimenez
Oct 12, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Yasuhiro IshiharaTakeshi Yamazaki
Jul 8, 2014·Frontiers in Aging Neuroscience·George E BarretoLuis Miguel Garcia-Segura
Jun 11, 2016·Progress in Neurobiology·Estefanía Acaz-FonsecaGeorge E Barreto
Sep 22, 2016·Neural Regeneration Research·Jennifer M Colón, Jorge D Miranda
May 20, 2016·Endocrine Reviews·Alessandro VillaAdriana Maggi

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