Neuroprotective Effects of Trolox, Human Chorionic Gonadotropin, and Carnosic Acid on Hippocampal Neurodegeneration After Ischemiareperfusion Injury

Current Stem Cell Research & Therapy
Asrin BabahajianSeyed Mohammad Amin Haramshahi

Abstract

One of the serious complications of stroke is memory impairment, which is considered as one of the complications of reperfusion of tissue. The present study was designed to compare the effect of administration of Trolox, carnosic acid and Human Chorionic Gonadotropin (HCG) immediately after reperfusion of the stroke tissue on the memory and hippocampal histology. Ischemia-Reperfusion Model (IRI) was created by bilateral occlusion of the common carotid artery for 15 minutes and the first dose was administered immediately after reperfusion. 10 days after ischemia, passive avoidance memory test and apoptotic protein levels were evaluated. Cerebral Ischemia perfusion reduced the time of latency in entering the dark box in the ischemic group. Administration of Trolox and HCG increased this latency time, while treatment with carnosic acid had no effect. Also, IRI significantly reduced the number of healthy cells in the hippocampus. Administration of Trolox, carnosic acid and HCG increased the number of healthy cells and decreased the expression of Caspase-3 and Bax, but significantly increased the expression of Bcl-2 compared to the ischemic group. Findings indicate the beneficial effects of HCG and Trolox on the improvement of memor...Continue Reading

References

Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Feb 26, 2000·Science·F H Gage
Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anke PostTheologos M Michaelidis
May 3, 2006·Biological & Pharmaceutical Bulletin·Sangeetha Gupta, Shyam Sunder Sharma
Jun 29, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sharyl R Martini, Thomas A Kent
Sep 26, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·L Colucci-D'AmatoU di Porzio
Mar 31, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Diana Conte CamerinoJean-François Desaphy
Mar 1, 2008·Neuropharmacology·Kristian P DoyleMary P Stenzel-Poore
Jun 25, 2008·Neuropharmacology·R W V FlynnA S F Doney
May 26, 2009·Brain Research·Ludmila BelayevSteven C Cramer
Feb 23, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Angela J Eykelbosh, Glen Van Der Kraak
Jun 22, 2010·Journal of Neuroendocrinology·T V NguyenC J Pike
Oct 20, 2010·Annals of the New York Academy of Sciences·Gregory J del Zoppo
Jan 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Koji AbeNobutaka Kawahara
Apr 13, 2012·Clinical Science·Ramaroson AndriantsitohainaIsmail Laher
Jun 13, 2012·Nutritional Neuroscience·Chien-Wei HouKee-Ching Jeng
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyunjung LeeMinWhan Jung
Sep 12, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dale Ding

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Related Papers

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Arash SarveazadMohammadreza Nourani
The Medical Letter on Drugs and Therapeutics
© 2022 Meta ULC. All rights reserved