Neuroprotective Effects of Vigabatrin on Spinal Cord Ischemia-Reperfusion Injury

World Neurosurgery
Emre DurdağNecdet Ceviker

Abstract

Spinal cord ischemia is a serious and catastrophic clinicopathologic condition. Despite studies reported over the last 20 years, alternative and efficient treatment options remain unclear. We examined the neuroprotective effects of vigabatrin on a spinal ischemia-reperfusion model. We divided 24 New Zealand rabbits into 4 groups (control, ischemia reperfusion, and low-dose and high-dose vigabatrin). The control group underwent only abdominal surgery, whereas an abdominal aortic cross-clamp model of spinal ischemia was performed in the other groups. Clips were removed after 30 minutes and 50 and 150 mg/kg vigabatrin was administered intraperitoneally to the low-dose and high-dose groups, respectively. Neurologic examination was performed for 48 hours, after which the rabbits were sacrificed and a blood sample obtained. Biochemical examination of malondialdehyde, advanced oxidation protein products, total nitric oxide, and glutathione levels and superoxide dismutase activities in plasma and tissue sample, and histopathologic examination of the spinal cord were performed and statistical results compared between the groups. Low-dose vigabatrin had statistically significant effects of neuroprotection on spinal ischemia. Although hig...Continue Reading

Citations

Apr 1, 2020·The Journal of Spinal Cord Medicine·Kevser TuralIrfan Tasoglu
Dec 10, 2019·Oxidative Medicine and Cellular Longevity·Chaoran ChenGuangli Lu
Sep 18, 2021·Journal of Neuropathology and Experimental Neurology·Hamdy AwadEsmerina Tili

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