Neuroprotective efficacy of estrogen in experimental spinal cord injury in rats.

Annals of the New York Academy of Sciences
Supriti SamantarayNaren L Banik

Abstract

Spinal cord injury (SCI) leads to neurological deficits and motor dysfunction. Methylprednisolone, the only drug used for treating SCI, renders limited neuroprotection and remains controversial. Estrogen is one of the most potent multiactive neuroprotective agents and it is currently under investigation in our laboratory for its efficacy in SCI. The present review briefly summarizes our earlier findings on the therapeutic potential of pharmacological/supraphysiological levels of estrogen in SCI and outlines our ongoing research, highlighting the efficacy of physiological levels of estrogen against neuronal injury, axonal degeneration, and gliosis and also the molecular mechanisms of such neuroprotection in experimental SCI. Furthermore, our ongoing studies designed to explore the different translational potential of estrogen therapy suggest that this multiactive steroid may act as an adjunct therapy to promote angiogenesis, thus enhancing the functional recovery following chronic SCI. Taken together, these studies confirm that estrogen is a potential therapeutic agent for treating SCI.

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Citations

Mar 5, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Swapan K RayNaren L Banik
Feb 3, 2012·European Journal of Histochemistry : EJH·L ObotiA Fasolo
Sep 6, 2013·Journal of Neurotrauma·Jutatip GuptarakOlivera Nesic
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Oct 16, 2015·Reviews in the Neurosciences·Mrinmay ChakrabartiSwapan K Ray
Dec 23, 2015·Neural Regeneration Research·Jeffrey P DattoDamien D Pearse
Jan 27, 2017·International Journal of Molecular Sciences·Dominic M MaggioDamien D Pearse
Apr 18, 2020·Growth Factors·María Del Carmen Díaz-GalindoJ Luis Quintanar
Jan 27, 2015·Neurochemical Research·Denisse Calderón-VallejoJ Luis Quintanar
Apr 17, 2018·Metabolic Brain Disease·Zeinab NamjooAdib Zendedel

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