Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion

Neuroscience
Hiroshi UedaS Maeda

Abstract

Prothymosin alpha (ProTα) has robustness roles against brain and retinal ischemia or serum-starvation stress. In the ProTα sequence, the active core 30-amino acid peptide/P30 (a.a.49-78) is necessary for the original neuroprotective actions against ischemia. Moreover, the 9-amino acid peptide sequence/P9 (a.a.52-60) in P30 still shows neuroprotective activity against brain and retinal ischemia, though P9 is less potent than P30. As the previous structure-activity relationship study for ProTα may not be enough, the possibility still exists that any sequence smaller than P9 retains potent neuroprotective activity. When different P9- and P30-related peptides were intravitreally injected 24h after retinal ischemia in mice, the 6-amino acid peptide/P6 (NEVDEE, a.a.51-56) showed potent protective effects against ischemia-induced retinal functional deficits, which are equipotent to the level of P30 peptide in electroretinography (ERG) and histological damage in Hematoxylin and Eosin (HE) staining. Further studies using ERG and HE staining suggested that intravitreal or intravenous (i.v.) injection with modified P6 peptide/P6Q (NEVDQE) potently inhibited retinal ischemia-induced functional and histological damage. In an immunohistochem...Continue Reading

References

Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A L SirénP Ghezzi
Feb 10, 2004·Progress in Retinal and Eye Research·Neville N OsborneJosé Melena
Apr 23, 2004·Expert Opinion on Biological Therapy·Allan L Goldstein, Mahnaz Badamchian
Sep 29, 2004·Toxicology and Applied Pharmacology·Masako KumadaOsamu Kozawa
Oct 20, 2004·Trends in Pharmacological Sciences·Kenneth MaieseZhao Zhong Chong
Jan 20, 2005·Molecular and Cellular Biology·Ruben N KarapetianAndrey B Vartapetian
Jun 30, 2007·Cell Death and Differentiation·R Fujita, H Ueda
Jan 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wei WangOtto W Witte
Apr 14, 2009·Current Atherosclerosis Reports·Myriam Fornage
Jul 21, 2009·The European Journal of Neuroscience·Galina DvoriantchikovaDmitry Ivanov
Aug 12, 2009·Clinical Ophthalmology·Charanjit KaurEng-Ang Ling
Apr 20, 2010·Future Neurology·Jonathan R WeinsteinThomas Möller
Jun 12, 2010·Annals of the New York Academy of Sciences·Bonifazi PierluigiLuigina Romani
Jun 12, 2010·Annals of the New York Academy of Sciences·Hiroshi UedaMutsumi Ueda
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yanxin Zhao, David A Rempe
Nov 16, 2010·Neurochemistry International·Yannick BéjotChristine Marie
Feb 26, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Oscar J Cordero
Apr 28, 2011·Central Nervous System Agents in Medicinal Chemistry·George BarretoRona G Giffard
Jun 2, 2011·Current Neuropharmacology·Xiyong FanFrank van Bel
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melanie A SamuelJoshua R Sanes
Nov 24, 2011·The Journal of Biological Chemistry·Gaofeng DongHongmin Wang
Mar 1, 2012·Cancer Immunology, Immunotherapy : CII·Kyriaki IoannouOurania E Tsitsilonis
May 18, 2012·Frontiers in Neurology·Gillipsie MinhasAkshay Anand
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Irina De la HuertaJoshua R Sanes
Oct 11, 2012·Annals of the New York Academy of Sciences·Hiroshi UedaSebok Kumar Halder
Dec 4, 2012·Acta Pharmacologica Sinica·Philippe M D'Onofrio, Paulo D Koeberle
Dec 21, 2012·Chemical Biology & Drug Design·David J CraikDavid Price
Jan 2, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ioannis F VoutsasAristotelis Bamias
Jan 3, 2013·Journal of Neurochemistry·Sebok Kumar HalderHiroshi Ueda
Feb 1, 2013·Mediators of Inflammation·Roberto dell'OmoCiro Costagliola
Feb 6, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ellen C Jensen
Feb 12, 2013·Medical Hypotheses·Hiroto IshikawaCesar V Borlongan
Jul 17, 2013·Apoptosis : an International Journal on Programmed Cell Death·Alessandro CannavoGiovanni Esposito

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Citations

Aug 12, 2017·PloS One·Stephanie C JoachimH Burkhard Dick
Feb 7, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M GlaserS C Joachim
Jan 9, 2020·Clinical and Experimental Nephrology·Kenta TorigoeTomoya Nishino
Nov 7, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroshi Ueda

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