Neuroprotective limonoids of root bark of Dictamnus dasycarpus

Journal of Natural Products
Jeong Seon YoonYoung Choong Kim

Abstract

A methanolic extract of Dictamnus dasycarpus root bark afforded four new degraded limonoids, 9alpha-hydroxyfraxinellone-9- O-beta- d-glucoside ( 1), dictamnusine ( 2), dictamdiol A ( 3), and dictamdiol B ( 4), together with eight known compounds, dictamdiol ( 5), fraxinellone ( 6), fraxinellonone ( 7), 9beta-hydroxyfraxinellone ( 8), calodendrolide ( 9), obacunone ( 10), limonin ( 11), and rutaevin ( 12). Compounds, 2, 3, 6, 9, 10, and 11 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM.

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Citations

Feb 16, 2010·Journal of Molecular Neuroscience : MN·Jeong Seon YoonYoung Choong Kim
Nov 23, 2013·Journal of Agricultural and Food Chemistry·Yong GuoHui Xu
Dec 15, 2015·Pharmacognosy Magazine·Hyun Soo ParkByung Joo Kim
Jun 13, 2015·Journal of Ethnopharmacology·Mengying LvJianbo Sun
Aug 11, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Jeong Seon YoonYoung Choong Kim
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Rosa TundisFrancesco Menichini
Oct 30, 2016·Fitoterapia·Jian-Bo SunLi Chen
Nov 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta GualdaniSolomon Habtemariam
Mar 5, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min LüHuixia Liu
Dec 22, 2009·Natural Product Reports·Joseph D Connolly, Robert A Hill
May 20, 2017·World Journal of Gastroenterology : WJG·Lin LiYang Xu
Oct 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shunming FanLingying Yu
Jul 19, 2011·Chemistry & Biodiversity·Xue GaoJing-Feng Hu
Apr 29, 2020·Bulletin of Environmental Contamination and Toxicology·Ji LeiZongxiao Li
Aug 13, 2020·Antibiotics·Marta Ferrera-SuanzesMaría Jesús Durán-Peña
Dec 22, 2020·Frontiers in Pharmacology·María José Larrazábal-FuentesJavier Echeverría
Apr 7, 2009·The Journal of Organic Chemistry·Leiv K SydnesMiriam Hanstein
Oct 28, 2020·Journal of Agricultural and Food Chemistry·Yan-Hui FuYan-Ping Liu
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biswadeep DasAkash Agnihotri
Mar 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tao WeiXiaoying Zhou

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