Neuroprotective measures throughout the TAVI pathway

Minerva cardioangiologica
Arthur Shiyovich, Ran Kornowski

Abstract

Aortic stenosis (AS) is the most common clinical valvular heart disorder that warrants active treatment. Symptomatic and severe AS is associated with increased morbidity and mortality if left untouched. Transcatheter aortic valve implantation (TAVI) is an innovative therapeutic modality approved initially for patients with prohibitive surgical risk and subsequently became a mainstream practice and the preferred treatment modality for many patients with severe AS at high and moderate surgical risk. Consistently global TAVI volumes have increased and indications continue to widen toward younger and lower-risk patients. However, periprocedural stroke is one of the most feared complications of TAVI, and when clinically evident, it is often associated with significant increase in mortality, physical disability, social isolation and financial costs. Furthermore, even when clinically overt stroke is not evident following TAVI, highly sensitive imaging modalities have demonstrated new post-procedural ischemic lesions in most patients. Although little is known about the long-term clinical significance of these lesions, there are strong signals showing they might be related with reduced subsequent neurocognitive function. This review pro...Continue Reading

References

Mar 28, 2003·The New England Journal of Medicine·Sarah E VermeerMonique M B Breteler
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerUNKNOWN Rotterdam Scan Study
Oct 8, 2004·The New England Journal of Medicine·Jay S YadavUNKNOWN Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy Investigators
Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Nov 23, 2010·JACC. Cardiovascular Interventions·Martin ArnoldJosef Ludwig
Nov 23, 2010·JACC. Cardiovascular Interventions·Fabian NietlispachJohn G Webb
Dec 28, 2010·Journal of the American College of Cardiology·Josep Rodés-CabauJohn G Webb
Jan 25, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Parla AstarciCécile Grandin
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Sep 13, 2011·The American Journal of Cardiology·Gian Paolo UssiaCorrado Tamburino
Feb 4, 2012·Journal of the American College of Cardiology·David R HolmesJames D Thomas
Mar 7, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Holger EggebrechtRajendra H Mehta
Mar 10, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christoph K NaberEberhard Grube
Mar 17, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gabor ErdoesBalthasar Eberle
Mar 20, 2012·The Journal of Thoracic and Cardiovascular Surgery·D Craig MillerUNKNOWN PARTNER Stroke Substudy Writing Group and Executive Committee
Mar 20, 2012·The American Journal of Cardiology·Rutger-Jan NuisPeter P de Jaegere
May 15, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Kevin OnseaPieter Stella
Aug 28, 2012·European Heart Journal·UNKNOWN Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC)Marian Zembala
Oct 3, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arie Pieter KappeteinUNKNOWN Valve Academic Research Consortium (VARC)-2
May 9, 2013·Stroke; a Journal of Cerebral Circulation·Ralph L SaccoUNKNOWN Council on Nutrition, Physical Activity and Metabolism
Apr 1, 2014·The New England Journal of Medicine·David H AdamsUNKNOWN U.S. CoreValve Clinical Investigators
Apr 3, 2014·Circulation·Steven R MesséUNKNOWN Determining Neurologic Outcomes from Valve Operations (DeNOVO) Investigators
Oct 21, 2014·Journal of Stroke·Bum Joon KimDong-Wha Kang
Dec 3, 2014·The Journal of Thoracic and Cardiovascular Surgery·Mariam SamimPieter R Stella
Jan 13, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Jacob T GutscheJohn G T Augoustides
Jan 19, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Mariam SamimPieter R Stella
Mar 11, 2015·JAMA : the Journal of the American Medical Association·David R HolmesUNKNOWN STS/ACC TVT Registry
Apr 15, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Andreas BaumbachAlexandra J Lansky
May 7, 2015·JACC. Cardiovascular Interventions·Nicolas M Van MieghemPeter P de Jaegere
Jun 30, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Michael FabbroFrederic C Cobey

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