Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: therapeutic implications for Huntington's disease

Annals of the New York Academy of Sciences
Chia-Lin WuDing-I Yang

Abstract

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial succinate dehydrogenase that has been used to explore the molecular mechanisms of cell death associated with mitochondrial dysfunction and neurodegeneration for Huntington's disease (HD). Brain-derived neurotrophic factor (BDNF) is a neurotrophin that may regulate neuronal survival and differentiation. Experimental evidence derived from both clinical as well as basic research suggests a close association between BDNF deficiency and HD pathogenesis. In this review, we focus on recent progress in the molecular mechanisms responsible for the BDNF-mediated neuroprotective effects against mitochondrial dysfunction induced by 3-NP. Delineation of BDNF-mediated neuroprotective actions against 3-NP toxicity may add in the development of therapeutic intervention for HD where mitochondrial dysfunction is known to play a crucial role in pathogenesis of this devastating disease.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T A AlstonH J Bright
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·E BrouilletM F Beal
May 29, 2000·Brain Research·I FerrerT Ribalta
Jun 29, 2002·Nature Neuroscience·Alexander V PanovJ Timothy Greenamyre
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sang Y LeeChuang C Chiueh
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jieli ChenMichael Chopp
Mar 8, 2005·Free Radical Biology & Medicine·Tzyh-Chwen JuDing-I Yang
Mar 24, 2007·Progress in Neurobiology·Chiara Zuccato, Elena Cattaneo
Sep 13, 2008·Journal of Neurochemistry·Manabu HashimotoChihiro Akazawa
Mar 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle A SimmonsGary Lynch
May 9, 2009·Biochemical and Biophysical Research Communications·Chia-Lin WuDing-I Yang
Jun 27, 2009·Neurobiology of Disease·Sandra AlmeidaA Cristina Rego
Aug 18, 2009·Biochimica Et Biophysica Acta·Maria DamianoEmmanuel Brouillet

❮ Previous
Next ❯

Citations

Jul 15, 2011·Journal of Inherited Metabolic Disease·Megan E BreuerJan A M Smeitink
Oct 6, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Abdellatif Benraiss, Steven A Goldman
Mar 29, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Denny Joseph K M, Muralidhara
Mar 5, 2014·Neurological Research·Leandro C SouzaCristiano R Jesse
Dec 20, 2017·Journal of Huntington's Disease·Danielle A Simmons
Aug 18, 2018·International Journal of Molecular Sciences·Shang-Der ChenDing-I Yang
Jul 22, 2019·Journal of Clinical Medicine·Shang-Der ChenDing-I Yang
Mar 10, 2017·International Journal of Molecular Sciences·Shang-Der ChenDing-I Yang
Jul 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yanqiu JiaWei Jin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.