Neuroprotective Peptides in Retinal Disease

Journal of Clinical Medicine
Davide CerviaGiovanni Casini

Abstract

In the pathogenesis of many disorders, neuronal death plays a key role. It is now assumed that neurodegeneration is caused by multiple and somewhat converging/overlapping death mechanisms, and that neurons are sensitive to unique death styles. In this respect, major advances in the knowledge of different types, mechanisms, and roles of neurodegeneration are crucial to restore the neuronal functions involved in neuroprotection. Several novel concepts have emerged recently, suggesting that the modulation of the neuropeptide system may provide an entirely new set of pharmacological approaches. Neuropeptides and their receptors are expressed widely in mammalian retinas, where they exert neuromodulatory functions including the processing of visual information. In multiple models of retinal diseases, different peptidergic substances play neuroprotective actions. Herein, we describe the novel advances on the protective roles of neuropeptides in the retina. In particular, we focus on the mechanisms by which peptides affect neuronal death/survival and the vascular lesions commonly associated with retinal neurodegenerative pathologies. The goal is to highlight the therapeutic potential of neuropeptide systems as neuroprotectants in retin...Continue Reading

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Citations

Aug 5, 2020·Cellular and Molecular Life Sciences : CMLS·Elisabetta CatalaniDavide Cervia
Jan 22, 2020·Neural Regeneration Research·Elisabetta Catalani, Davide Cervia
Dec 4, 2019·Frontiers in Neuroscience·Maria Grazia RossinoGiovanni Casini
Feb 12, 2021·Zebrafish·Louise Oliveira FiamettiLeandro Mantovani de Castro
Oct 30, 2020·Translational Vision Science & Technology·Renee C RyalsMark E Pennesi
Feb 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elisabetta CatalaniDavide Cervia
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Cemal OrhanKazim Sahin
Jun 3, 2021·International Journal of Molecular Sciences·Ivan T RebustiniS Patricia Becerra

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