PMID: 11905991Mar 22, 2002Paper

Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1

Journal of Neurochemistry
Giovanni MarsicanoChristian Behl

Abstract

Neuroprotective effects have been described for many cannabinoids in several neurotoxicity models. However, the exact mechanisms have not been clearly understood yet. In the present study, antioxidant neuroprotective effects of cannabinoids and the involvement of the cannabinoid receptor 1 (CB1) were analysed in detail employing cell-free biochemical assays and cultured cells. As it was reported for oestrogens that the phenolic group is a lead structure for antioxidant neuroprotective effects, eight compounds were classified into three groups. Group A: phenolic compounds that do not bind to CB1. Group B: non-phenolic compounds that bind to CB1. Group C: phenolic compounds that bind to CB1. In the biochemical assays employed, a requirement of the phenolic lead structure for antioxidant activity was shown. The effects paralleled the protective potential of group A and C compounds against oxidative neuronal cell death using the mouse hippocampal HT22 cell line and rat primary cerebellar cell cultures. To elucidate the role of CB1 in neuroprotection, we established stably transfected HT22 cells containing CB1 and compared the protective potential of cannabinoids with that observed in the control transfected HT22 cell line. Furtherm...Continue Reading

Citations

Jul 2, 2003·Neurotoxicity Research·Mario van der SteltHarald S Hansen
Mar 31, 2006·Psychopharmacology·S A VarvelB R Martin
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·L ChangT Ernst
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Allyn C HowlettDerek C Norford
Aug 19, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Shuxian HuRobert Bryan Rock
May 17, 2005·Journal of the Neurological Sciences·Samuel J JacksonDavid Baker
Jun 28, 2003·Brain Research. Molecular Brain Research·José Martínez-OrgadoM Paz Viveros
Jul 11, 2002·Free Radical Biology & Medicine·Christian Behl, Bernd Moosmann
Jan 25, 2003·Free Radical Biology & Medicine·Victoria C Stewart, Simon J R Heales
Dec 9, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Olov NilssonChristopher J Fowler
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Silvia ZoppiBorja García-Bueno
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Onder AlbayramAndras Bilkei-Gorzo
Apr 12, 2011·Journal of Clinical and Experimental Neuropsychology·Raul GonzalezEileen M Martin
Mar 12, 2013·Antioxidants & Redox Signaling·Djordje Miljković, Ivan Spasojević
Jul 1, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anna-Maria SzczesniakOrlando Hung
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andras Bilkei-Gorzo
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Apr 20, 2004·The British Journal of Ophthalmology·I TomidaA Azuara-Blanco
Aug 6, 2008·Pediatric Research·Francisco J AlvarezJosé Martínez-Orgado
May 23, 2014·PloS One·M Paola CastelliM Grazia Ennas
Oct 24, 2007·Molecular Neurobiology·Onintza SagredoJavier Fernández-Ruiz
Jul 20, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Teresa IuvoneUNKNOWN Endocannabinoid Research Group
Jun 16, 2014·Neuromolecular Medicine·Esmée Vendel, Elizabeth C M de Lange
Oct 15, 2011·Cellular and Molecular Life Sciences : CMLS·Akhlaq A FarooquiVincenza Frisardi
Jun 16, 2011·The International Journal of Neuroscience·Henrik Hasseldam, Flemming Fryd Johansen
Nov 1, 2009·Expert Review of Clinical Pharmacology·Eva de LagoJavier Fernández-Ruiz
Feb 16, 2016·Autoimmunity Reviews·Valeria KatchanYehuda Shoenfeld
Mar 22, 2006·Expert Opinion on Investigational Drugs·Ben A BahrAlexandros Makriyannis
Jul 19, 2005·Expert Opinion on Investigational Drugs·Lara Teare, John Zajicek
Oct 22, 2002·Expert Opinion on Investigational Drugs·Robert I Grundy
Mar 19, 2011·Archivos de la Sociedad Española de Oftalmología·S Pinar-SueiroE Vecino
Mar 23, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A J Sánchez, A García-Merino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.