Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

International Journal of Molecular Sciences
Debora CutuliLaura Petrosini

Abstract

As major components of neuronal membranes, omega-3 polyunsaturated fatty acids (n-3 PUFA) exhibit a wide range of regulatory functions. Recent human and animal studies indicate that n-3 PUFA may exert beneficial effects on aging processes. Here we analyzed the neuroprotective influence of n-3 PUFA supplementation on behavioral deficits, hippocampal neurogenesis, volume loss, and astrogliosis in aged mice that underwent a selective depletion of basal forebrain cholinergic neurons. Such a lesion represents a valid model to mimic a key component of the cognitive deficits associated with dementia. Aged mice were supplemented with n-3 PUFA or olive oil (as isocaloric control) for 8 weeks and then cholinergically depleted with mu-p75-saporin immunotoxin. Two weeks after lesioning, mice were behaviorally tested to assess anxious, motivational, social, mnesic, and depressive-like behaviors. Subsequently, morphological and biochemical analyses were performed. In lesioned aged mice the n-3 PUFA pre-treatment preserved explorative skills and associative retention memory, enhanced neurogenesis in the dentate gyrus, and reduced volume and VAChT levels loss as well as astrogliosis in hippocampus. The present findings demonstrating that n-3 P...Continue Reading

References

Aug 19, 1991·Neuroscience Letters·H FillitG Wolf-Klein
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanF Morrell
Jul 30, 1982·Science·R T BartusA S Lippa
Mar 24, 1997·The Journal of Comparative Neurology·G SimićN Bogdanović
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·P T FrancisG K Wilcock
Feb 15, 2001·Journal of Neuroscience Research·P K DashA N Moore
Feb 24, 2001·Depression and Anxiety·A GarauF Balada
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Jul 11, 2001·Neurobiology of Aging·T L JerniganJ R Hesselink
Apr 5, 2002·Neuropsychologia·Stephan HamannFelicia C Goldstein
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M R LampreaS Morato
May 6, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marianne Haag
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gwendolyn Barceló-CoblijnTibor Farkas
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Jun 5, 2004·Ageing Research Reviews·Tibor Kovács
Jun 26, 2004·The European Journal of Neuroscience·Christopher L HunterAnn-Charlotte Granholm
Aug 25, 2004·Behavioural Brain Research·Stéphanie PothionCatherine Belzung
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Feb 19, 2005·Neurobiology of Aging·Paul MohapelOlle Lindvall
Sep 20, 2005·Experimental Neurology·Sebastian JessbergerGerd Kempermann
Feb 14, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Magdalena SastreMichael T Heneka
Mar 28, 2006·Neuroscience·I DriscollR J Sutherland
May 23, 2006·Neurobiology of Aging·Aileen M LynchMarina A Lynch
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·Eliezer MasliahLawrence Hansen
Sep 16, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Irina Fedorova, Norman Salem
Sep 20, 2006·Journal of Neurochemistry·Rebecca GriffinMarina A Lynch
Sep 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Naoko KanekoKazunobu Sawamoto
Mar 22, 2007·The Journal of Nutrition·Sheila M Innis
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
May 22, 2008·Brain : a Journal of Neurology·M HoeferH J Rosen
Jun 26, 2008·Neuroscience and Biobehavioral Reviews·Lorey K TakahashiMark L Pilar
Oct 10, 2008·PLoS Biology·Stefano Farioli-VecchioliFelice Tirone

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Citations

Sep 26, 2020·Neuroscience Letters·Yi-Ran BaiRu-Ling Shi

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Methods Mentioned

BETA
confocal microscopy
light microscopy

Software Mentioned

ImageJ
Statistica
EthoVision
EthoVision XT
Statsoft

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