Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity

Biogerontology
Anil K ManthaNajma Z Baquer

Abstract

The brain tissue has a large oxidative capacity, but its ability to combat oxidative stress is limited. In aging brain tissue the oxidative stress increases due to decreased activity of antioxidant enzymes and increased oxidative stress leading to neurodegeneration associated with excitotoxicity. The aim of the present study was to determine the effect of neuropeptides, neurokinin B (NKB) and amyloid beta protein fragment Abeta (25-35) and neurotransmitters N-methyl D-aspartate (NMDA) and Glutamate on rat brain synaptosomes of different age groups. Aging brain functions were assessed by measuring the activities of superoxide dismutase (Mn-SOD) and monoamine oxidase (MAO) and intrasynaptosomal [Ca(2+)](i )levels in presence of neuropeptides and neurotransmitters. Increase in age decreased the SOD and MAO enzyme activities; Abeta (25-35) addition further had damaging/toxic effects on the enzymes, whereas NKB alone and in combination with amyloid lowered the toxic effects caused by Abeta (25-35) addition, which was concentration (peptide) and age dependent. Oxidative stress and excitotoxicity are major consequences associated with the age, [Ca(2+)](i )was increased with the age and the neuropeptides and neurotransmitters elicited ...Continue Reading

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Citations

Jan 20, 2010·Journal of Neuropathology and Experimental Neurology·Mubeen A Ansari, Stephen W Scheff
Mar 1, 2011·Biochemical and Biophysical Research Communications·Efrat FlashnerAssaf Friedler
Mar 31, 2011·Geriatrics & Gerontology International·Elcin E UmurYasar Kucukardali
Mar 8, 2016·Journal of Inorganic Biochemistry·Reeha ShahzadChristopher E Jones
Feb 12, 2021·The Journal of Physical Chemistry. B·Shira Ben-Shushan, Yifat Miller

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