Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)

Neuroscience Letters
Emma Muñoz-SaezBegoña Gómez Miguel

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.

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Citations

Aug 3, 2016·Medicinal Research Reviews·Dominik Vogt, Holger Stark
Nov 9, 2016·Neuropharmacology·Sinead O'Sullivan, Kumlesh K Dev
Jul 19, 2017·Molecular Neurobiology·Juan Andrés PargaJannette Rodríguez-Pallares
Jul 13, 2016·Scientific Reports·Ann Kristin FrøysetKari Espolin Fladmark
Aug 21, 2019·Frontiers in Pharmacology·Sara GrassiPaola Giussani
Aug 28, 2021·International Journal of Molecular Sciences·Paola SiniClaudia Crosio

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