Neuroprotective therapies for glaucoma

Drug Design, Development and Therapy
Wei SongChun Zhang

Abstract

Glaucoma is the second leading cause for blindness worldwide. It is mainly caused by glaucomatous optic neuropathy (GON) characterized by retinal ganglion cell loss, which leads to visual field defect and blindness. Up to now, the main purpose of antiglaucomatous therapies has been to lower intraocular pressure (IOP) through surgeries and medications. However, it has been found that progressive GON is still present in some patients with effective IOP decrease. Therefore, risk factors other than IOP elevation, like neurotrophin deprivation and excitotoxicity, contribute to progressive GON. Novel approaches of neuroprotection may be more effective for preserving the function of the optic nerve.

Citations

Apr 20, 2016·Frontiers in Aging Neuroscience·Pawel GriebRobert Rejdak
Mar 13, 2017·Parkinsonism & Related Disorders·Merel S EkkerBastiaan R Bloem
Jan 2, 2018·BioResearch Open Access·Walter H MoosKrishna Kodukula
Sep 24, 2019·Frontiers in Neuroscience·Teresa TsaiStephanie C Joachim
Jan 14, 2016·Military Medical Research·Eric L SingmanTimothy McCulley
Dec 13, 2018·Neural Regeneration Research·Annagrazia AdornettoVincenzo Parisi
Feb 9, 2018·Frontiers in Pharmacology·Ana C Rodrigues-NevesAna R Santiago
Dec 14, 2018·Frontiers in Neuroscience·Marita Pietrucha-DutczakAdrian Smedowski
Feb 15, 2021·Survey of Ophthalmology·Luciano QuarantaIvano Riva
Dec 31, 2020·Pharmaceutics·Ognjenka RahićEdina Vranić

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT00141882
NCT00168350

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Expert Opinion on Therapeutic Targets
Travis J Good, Malik Y Kahook
The Cochrane Database of Systematic Reviews
Dayse F SenaKristina Lindsley
The Cochrane Database of Systematic Reviews
Dayse F Sena, Kristina Lindsley
© 2021 Meta ULC. All rights reserved