Neuroproteomics Studies: Challenges and Updates

Methods in Molecular Biology
Naify RamadanFiras H Kobeissy

Abstract

The Human Genome Project in 2003 has resulted in the complete sequence of ~99% of the human genome paving the road for the Human Proteome Project (HPP) assessing the full characterization of the translated protein map of the 20,300 protein-coding genes. Consequently, the emerging of the proteomics field has successfully been adopted as the method of choice for the proteome characterization. Proteomics is a term that is used to encompass multidisciplinary approaches combining different technologies that aim to study the entire spectrum of protein changes at a specific physiological condition. Proteomics research has shown excellent outcomes in different fields, among which is neuroscience; however, the complexity of the nervous systems necessitated the genesis of a new subdiscipline of proteomics termed as "neuroproteomics." Neuroproteomics studies involve assessing the quantitative and qualitative aspects of nervous system components encompassing global dynamic events underlying various brain-related disorders ranging from neuropsychiatric disorders, degenerative disorders, mental illness, and most importantly brain-specific neurotrauma-related injuries. In this introductory chapter, we will provide a brief historical perspecti...Continue Reading

Citations

Oct 17, 2018·Journal of Neurochemistry·Ubadah SabbaghMichael A Fox
Jan 26, 2021·Frontiers in Molecular Neuroscience·Amanda M do CantoIscia Lopes-Cendes
May 3, 2021·Molecular & Cellular Proteomics : MCP·Charlotte A G H van Gelder, Maarten Altelaar
Jul 18, 2021·Acta neurochirurgica·Sami Abu HamdehNiklas Marklund

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