Neuropsychiatric and Cognitive Subtypes among Community-Dwelling Older Persons and the Association with DSM-5 Mild Neurocognitive Disorder: Latent Class Analysis

Journal of Alzheimer's Disease : JAD
Tau Ming LiewLei Feng

Abstract

Neuropsychiatric symptoms (NPS) have been shown to increase the risk of neurocognitive disorders (NCD), leading to the recently-published criteria of mild behavioral impairment (MBI) to identify pre-dementia using NPS alone. However, MBI drew concerns about over-diagnosing subclinical psychiatric disorders. We hypothesized that the specificity of NPS in predicting NCD may be improved by considering NPS together with various domains of cognitive deficits. We tested this hypothesis by identifying subtypes based on the combination of NPS and cognitive deficits among community-dwelling older persons, and evaluating how the identified subtypes were associated with mild NCD. Our participants were from a community-based cohort study. They completed assessments such as Geriatric Depression Scale (GDS), Geriatric Anxiety Inventory (GAI), and Montreal Cognitive Assessment (MoCA). Those with possible cognitive impairment underwent further evaluations for mild NCD. Latent class analysis was conducted using GDS, GAI, and MoCA domains. Logistic regression was performed to investigate the association between the latent-classes and mild NCD. We included 825 participants, and identified four distinct subtypes: Subtype 1 (no NPS or cognitive def...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1995·Journal of the American Geriatrics Society·R J MillerR Vaughan
Aug 1, 1993·Archives of Neurology·J L Cummings
Jan 1, 1996·International Psychogeriatrics·S R AuerB Reisberg
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Apr 29, 2006·Dementia and Geriatric Cognitive Disorders·Minglei LiSoo Meng Ko
Jun 30, 2006·International Psychogeriatrics·Nancy A PachanaElizabeth Arnold
Dec 1, 2006·The Journal of Neuropsychiatry and Clinical Neurosciences·Hiroshi HashimotoDavid L Sultzer
Apr 26, 2007·Clinical Medicine & Research·Wee Shiong LimSuresh Sahadevan
Jul 12, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Lars Bäckman
Jun 23, 2009·Journal of Alzheimer's Disease : JAD·Roberto MonasteroRosolino Camarda
Feb 22, 2012·Dementia and Geriatric Cognitive Disorders·Sebastian PalmqvistKatarina Nägga
May 16, 2012·Epidemiology·Iris EekhoutMartijn W Heymans
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·M E PetersUNKNOWN Cache County Investigators
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Paul B RosenbergConstantine G Lyketsos
Apr 5, 2014·The American Journal of Psychiatry·Yonas E GedaWalter A Rocca
Aug 26, 2014·International Journal of Alzheimer's Disease·Jing XiaMonika Ray
Jan 16, 2015·Neurology·Mary Clare MastersCatherine M Roe
Feb 7, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Kristin ReynoldsJitender Sareen
Jun 6, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Matthew BaumgartHarry Johns
Jun 23, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Zahinoor IsmailUNKNOWN ISTAART Neuropsychiatric Symptoms Professional Interest Area
Aug 30, 2016·Neuroscience and Biobehavioral Reviews·Marco CanevelliMatteo Cesari
Jan 7, 2017·Journal of Alzheimer's Disease : JAD·Zahinoor IsmailUNKNOWN NPS Professional Interest Area of the International Society of to Advance Alzheimer’s Research and Treatment (NPS-PIA of IST

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.