Neuropsychiatric Correlates of Narcolepsy

Current Psychiatry Reports
Ahmed S BaHammamSeithikuruppu R Pandi-Perumal

Abstract

The complex nature of narcolepsy symptoms, along with the use of stimulants and anticataplectic medications, poses diagnostic difficulties in terms of underlying neuropsychiatric comorbidities. This study reviews recent evidence for the association between narcolepsy and neuropsychiatric disorders. We also critically analyze studies that have addressed the neuropsychiatric correlates of patients with narcolepsy, with a discussion of the possible pathophysiological mechanisms linking narcolepsy and neuropsychiatric disorders. Neuropsychiatric manifestations are common among patients with narcolepsy as narcolepsy and some neuropsychiatric disorders share common clinical features. This may create challenges in making the correct diagnosis, and hence result in a delay in starting appropriate treatment. Comorbid neuropsychiatric manifestations in patients with narcolepsy include depression, anxiety, psychosis, rapid eye movement (REM) sleep behavior disorder, and cognitive impairment. Although hypocretin deficiency has been proposed as a pathophysiological mechanism underlying both narcolepsy and neuropsychiatric disorders, further research is necessary to identify the exact mechanisms. Narcolepsy patients often manifest comorbid ne...Continue Reading

References

Jan 1, 1991·The Journal of Nervous and Mental Disease·A B DouglassJ M Russell
Jan 1, 1996·Sleep·G J LammersA E Meinders
Apr 19, 2000·Lancet·A SchuldT Pollmächer
Feb 24, 2001·Psychiatry and Clinical Neurosciences·N TakeuchiH Maeda
Jul 2, 2002·The American Journal of Psychiatry·Shyam K Bhat, Redentor Galang
Jul 12, 2002·Annals of Neurology·Andreas SchuldThomas Pollmächer
Sep 6, 2003·Acta Psychiatrica Scandinavica·A SzucsP Halász
Nov 1, 2003·Sleep Medicine·A VourdasP J McKenna
Jul 1, 2006·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Sarah Laxhmi Chellappa, John Fontenele Araújo
Feb 22, 2007·Sleep·W T LongstrethGerald van Belle
Jun 30, 2007·Neuroscience Letters·Yu Kyeong KimSang Eun Kim
Aug 21, 2007·Diabetes Technology & Therapeutics·Norbert DahmenPeter Tonn
Mar 28, 2008·Sleep·Hal A Droogleever FortuynSabastiaan Overeem
Dec 26, 2008·Sleep Medicine·Anastasios BonakisAdrian Williams
Feb 13, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Y DauvilliersV Viot-Blanc
Mar 10, 2009·General Hospital Psychiatry·Hal A Droogleever FortuynSebastiaan Overeem
Feb 2, 2010·General Hospital Psychiatry·H A Droogleever FortuynSebastiaan Overeem
Feb 6, 2010·Sleep Medicine·Andrea O RossettiThierry Buclin
Mar 13, 2010·Annals of Neurology·Aurélie PonzSophie Schwartz
Jun 17, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Alexandra DimitrovaGert Jan Lammers
Mar 1, 2012·Sleep Medicine·Eun Yeon JooSeung Bong Hong
Apr 4, 2013·Journal of Attention Disorders·Edward J Modestino, Jeanna Winchester
Jun 5, 2013·Frontiers in Endocrinology·Michihiro MiedaTakeshi Sakurai
Aug 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Claire E H M DonjacourGert Jan Lammers
Nov 26, 2013·Sleep Medicine·Yu-Shu HuangFan-Ming Hwang
Dec 24, 2013·Current Psychiatry Reports·Fabio PizzaGiuseppe Plazzi
Mar 4, 2014·Sleep·Maurice M OhayonArun Bhattacharyya
May 9, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sawako TabuchiAkihiro Yamanaka
Aug 22, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Francesca CanellasEmmanuel Mignot
Sep 6, 2014·Frontiers in Neurology·Tomi SarkanenMarkku Partinen
Sep 26, 2014·Nature Neuroscience·Stephen V MahlerGary Aston-Jones
Aug 28, 2013·Journal of Obesity & Weight Loss Therapy·Kathryn E DemosRena R Wing
Dec 2, 2014·Sleep Medicine·Laura ZamarianBirgit Frauscher
Dec 2, 2014·Current Neurology and Neuroscience Reports·Sona Nevsimalova, Vera Malinova
Mar 11, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J J HendrikseM J Hayden
Jun 10, 2015·Sleep Medicine Clinics·Suresh Kotagal
Mar 1, 2014·Sleep Science·Hernán Andrés Marín AgudeloCarlos H Schenck
Jan 7, 2016·Current Psychiatry Reports·Shi-Bin LiLuis de Lecea

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Dec 1, 2020·Current Sleep Medicine Reports·Karen Spruyt

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