Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral prefrontal cortex in humans

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Edward D HueyJordan Grafman

Abstract

Animal evidence suggests that a brain network involving the medial and rostral ventral prefrontal cortex (PFC) is central for threat response and arousal and a network involving the lateral and caudal PFC plays an important role in reward learning and behavioral control. In this study, we contrasted the neuropsychiatric effects of degeneration of the medial versus lateral PFC in 43 patients with Frontotemporal dementia (FTD) and 11 patients with Corticobasal Syndrome (CBS) using MRI, the Neuropsychiatric Inventory (NPI), and the Sorting, Tower, Twenty Questions, and Fluency tests of the Delis-Kaplan Executive Function System (D-KEFS). Deviations in MRI grey matter volume from 86 age-matched healthy control subjects were determined for the patients using FreeSurfer. Multivariate regression was used to determine which brain areas were associated with specific neuropsychiatric and cognitive symptoms. Decreased grey matter volume of the right medial ventral PFC was associated with increased anxiety and apathy, decreased volume of the right lateral ventral PFC with apathy and inappropriate repetitive behaviors, and of the left lateral ventral PFC with poor performance on the sorting and Twenty Questions task in patients with FTD and...Continue Reading

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Citations

Jan 22, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Gayathri CheranEdward D Huey
Aug 14, 2018·European Journal of Pain : EJP·David KangSylvia M Gustin
Jun 20, 2017·American Journal of Physical Medicine & Rehabilitation·Sung Ho Jang, Hyeok Gyu Kwon
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Mar 30, 2020·The Journal of Nervous and Mental Disease·Edward D Huey
Jan 15, 2020·NeuroImage. Clinical·Jennifer L WhitwellKeith A Josephs
Jan 30, 2021·Seminars in Neurology·Katlyn Nemani, Lindsey Gurin

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