PMID: 9537268Apr 16, 1998Paper

Neuropsychiatric manifestations after mefloquine therapy for Plasmodium falciparum malaria: comparing a retrospective and a prospective study

Tropical Medicine & International Health : TM & IH
A M RønnI C Bygbjerg

Abstract

Mefloquine has been increasingly used for treatment of chloroquine-resistant malaria since its introduction in the late 1970s. In 1987 the first case of toxic encephalopathy was published, and in 1989 the WHO initiated reporting and investigation of neuropsychiatric adverse reactions of mefloquine. Neuropsychiatric adverse drug reactions are now well documented. We compared an open prospective 3 year study including all patients with P. falciparum treated with mefloquine with an earlier published, retrospective study on a comparable population from our department covering the period up to 1989. In the retrospective study neuropsychiatric adverse effects were not specifically asked for, while in the prospective study possible adverse reactions were registered daily according to a specified questionnaire. No case of neuropsychiatric adverse reaction was registered in the retrospective study. In the prospective study, 28% had one or more neuropsychiatric adverse reactions, although severity was mostly mild to moderate. Other adverse reactions occurred in 96% in the retrospective study compared to 81% in the prospective study. one often finds only what one looks for, e.g adverse events may be overlooked for a decade, if relatively ...Continue Reading

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Citations

Jan 6, 2012·The Pediatric Infectious Disease Journal·Remington L Nevin
Feb 24, 2006·Antimicrobial Agents and Chemotherapy·G DowK Cannard
Jan 29, 2009·Travel Medicine and Infectious Disease·Stephen Toovey
Jul 25, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Remington L Nevin
Sep 5, 2013·The American Journal of Tropical Medicine and Hygiene·Nongluk SeethornKesara Na-Bangchang
May 18, 2010·Journal of Clinical Psychopharmacology·Silvia YelmoRamón Gracia-Marco
Dec 2, 2010·The American Journal of Forensic Medicine and Pathology·Nathalie JoussetAntoine Tracqui
Oct 31, 2017·The Cochrane Database of Systematic Reviews·Maya Tickell-PainterDavid Sinclair
Apr 28, 2021·Critical Reviews in Toxicology·Airton C MartinsMichael Aschner

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