Neuropsychiatric side effects of FK506 vs. cyclosporine A. First-week postoperative findings

Psychosomatics
A F DiMartiniJ Fung

Abstract

The authors studied 31 liver transplant patients to compare neuropsychiatric side effects of a newer immunosuppressant, FK506, to cyclosporine A (CYA). Patients were randomly assigned to either FK506 or CYA. At the 1-week postoperative stage, cognitive status was assessed with the Mini-Mental State Exam, Trailmaking Tests (TMT) A and B, Delirium Rating Scale, and a neuropsychiatric symptom checklist. No statistically significant differences were found on any outcome variable between these two drugs, though scores on the TMTs were impaired as compared with published norms. The FK506 patients had moderately impaired TMT scores, whereas the CYA patients had only mild impairment. The patients demonstrate good cognitive recovery at 1 week post-transplantation, with only mild evidence of cognitive impairment.

Citations

Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T P Beresford
Apr 4, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia Burra, Manuela De Bona
Jan 31, 2012·Immunopharmacology and Immunotoxicology·Feng LiHong Shan Yin
Apr 1, 2017·The Cochrane Database of Systematic Reviews·Manuel Rodríguez-PerálvarezKurinchi Selvan Gurusamy

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