Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease

Parkinsonism & Related Disorders
Saul Martinez-HortaJaime Kulisevsky

Abstract

Neuropsychiatric symptoms are common features of Huntington's disease (HD). Whereas most studies have focused on cognitive and neuroimaging markers of disease progression, little is known about the prevalence of neuropsychiatric symptoms in premanifest mutation carriers far-from and close-to disease onset. We obtained neurological, cognitive and behavioral data from 230 participants classified as premanifest far-from (preHD-A) and close-to (preHD-B) motor-based disease onset, early-symptomatic (early-HD), and healthy controls. Frequency and severity of neuropsychiatric symptoms were assessed with the short Problem Behaviors Assessment for HD (PBA-s). The odds-ratio (OR) to present symptoms in the clinical range was calculated using the control group as reference. Logistic regression analysis was used to explore relationships between neuropsychiatric symptoms and medication use. Prevalence of depression was similar in all groups. Apathy was already present in 32% of preHD-A increasing to 62% of early-HD patients. The probability of presenting apathetic symptoms was 15-88 times higher in preHD-A and preHD-B respectively than in healthy controls. Irritability and executive dysfunction were present in both preHD-B and early-HD. Neu...Continue Reading

References

Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J KulisevskyJ L Cummings
Mar 18, 2004·Clinical Genetics·D R LangbehnUNKNOWN International Huntington's Disease Collaborative Group
Nov 30, 2006·Journal of Neurology·Richard Levy, Virginie Czernecki
Jan 11, 2007·Archives of Neurology·Jeanine MarshallTatiana Foroud
Jan 24, 2007·Lancet·Francis O Walker
May 8, 2007·Biological Psychiatry·Kevin DuffUNKNOWN Predict-HD Investigators of the Huntington Study Group
Sep 15, 2007·Brain : a Journal of Neurology·Robert Christian WolfDaniel Ecker
Sep 20, 2007·Psychosomatics·Marina VamosJohn Conaghan
Feb 23, 2008·General Hospital Psychiatry·Elisabeth M KingmaRaymund A C Roos
Nov 26, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Michael OrthG B Landwehrmeyer
Dec 18, 2010·Lancet Neurology·Christopher A Ross, Sarah J Tabrizi
Mar 28, 2012·The Journal of Neuropsychiatry and Clinical Neurosciences·Jennifer C ThompsonDavid Craufurd
Feb 22, 2013·Journal of the International Neuropsychological Society : JINS·Saül Martínez-HortaJaime Kulisevsky
Nov 28, 2013·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Lucienne van der MeerAad Tibben
May 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Erik van DuijnUNKNOWN European Huntington's Disease Network Behavioural Phenotype Working Group
Feb 27, 2015·The Journal of Neuropsychiatry and Clinical Neurosciences·Jenny CallaghanDavid Craufurd

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Citations

Dec 17, 2016·Journal of Huntington's Disease·Claudia Rangel-Barajas, George V Rebec
Mar 16, 2017·Human Brain Mapping·Peter McColganUNKNOWN Track On-HD Investigators
Mar 4, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Michel Saenz-FarretFederico Micheli
May 17, 2017·Current Opinion in Neurology·Clara Garcia-GorroRuth de Diego-Balaguer
Apr 21, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Saul Martínez-HortaJaime Kulisevsky
Feb 27, 2019·Journal of the International Neuropsychological Society : JINS·Maria B MisiuraUNKNOWN PREDICT-HD Investigators & Working Group
Jan 18, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L A Barboza, N C Ghisi
Feb 17, 2017·Journal of the International Neuropsychological Society : JINS·Maria B MisiuraUNKNOWN PREDICT-HD Investigators & Working Group
Apr 2, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Kate L HarrisRoger A Barker
Aug 20, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Noelle E CarlozziJane S Paulsen
Feb 20, 2020·Movement Disorders Clinical Practice·Malco RossiMarcelo Merello
Oct 1, 2016·Dementia & Neuropsychologia·Antonio Lucio TeixeiraEdward C Lauterbach
Jul 25, 2018·Current Protocols in Neuroscience·Claudia Rangel-Barajas, George V Rebec
Sep 7, 2018·Neural Plasticity·Cristine de Paula Nascimento-CastroPatricia S Brocardo
Aug 27, 2019·Frontiers in Neurology·Christopher J HeathBarbara J Sahakian
Jan 4, 2020·Brain Imaging and Behavior·Saul Martinez-HortaJaime Kulisevsky
Jan 11, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Frederic SampedroJaime Kulisevsky
May 31, 2018·Journal of Huntington's Disease·Elena Bellosta DiagoJavier López Del Val
Aug 15, 2018·Neural Regeneration Research·Daniel Zielonka
Aug 31, 2019·AJNR. American Journal of Neuroradiology·F SampedroJ Kulisevsky
Jul 25, 2019·Frontiers in Neurology·Anne-Catherine Bachoud-LéviJean-Marc Burgunder
Mar 3, 2020·Frontiers in Neuroscience·Sonja Blumenstock, Irina Dudanova
Feb 18, 2020·Psychological Medicine·S C AndrewsUNKNOWN TRACK-HD Investigators
Oct 27, 2017·Neuro-degenerative Diseases·Ana Rita Saldanha Ramos, Carolina Garrett
Dec 7, 2018·Open Biology·Yi-Ting HsuYijuang Chern
Aug 20, 2019·Journal of Huntington's Disease·Noelle E CarlozziRebecca E Ready
May 18, 2020·Journal of Huntington's Disease·Nicholas E KaragasErin Furr Stimming
Aug 12, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jane SimpsonFiona J R Eccles
Dec 31, 2020·Cell Reports Medicine·Kelly J AtkinsTrevor T-J Chong
Nov 2, 2020·Experimental Brain Research·Marta Olivetti BelardinelliSimone Migliore
Dec 4, 2020·International Journal of Molecular Sciences·Katie AndrewsJinwei Zhang
Aug 12, 2019·NeuroImage. Clinical·Audrey E De PaepeEstela Camara
Apr 6, 2021·Movement Disorders Clinical Practice·Kelly J AtkinsJulie C Stout
Apr 13, 2021·Brain : a Journal of Neurology·Joseph MoleDiana Caine
Mar 27, 2021·Neurology·Branduff McAllisterUNKNOWN REGISTRY Investigators of the European Huntington's Disease Network
Jun 24, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jenny CeccariniKoen Van Laere
Jun 15, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marcin LeśniakJoanna Seniów
Nov 12, 2021·Annals of Clinical and Translational Neurology·Frederic SampedroJaume Kulisevsky

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