Neuropsychiatric symptoms in older people with and without cognitive impairment

Journal of Alzheimer's Disease : JAD
Henry BrodatyPerminder S Sachdev

Abstract

Neuropsychiatric symptoms (NPS) are non-cognitive disturbances such as depression. Rates of NPS have been shown to increase as cognitive ability declines and may be useful in predicting transition from mild cognitive impairment (MCI) to dementia. This community-based study reports the association between NPS and cognitive decline over two years. Participants included 873 community dwelling adults aged 70-90 years enrolled in the Sydney Memory and Ageing Study. NPS were assessed by the Neuropsychiatric Inventory (NPI). Cognitive impairment was defined by diagnosis (MCI or incident dementia) or neuropsychological test performance across five cognitive domains. Cognitive decline was defined by progression to dementia or worse neuropsychological performance. Total NPS at baseline did not differ between those without cognitive impairment (26.2%) and those with MCI (28.8%), but agitation and apathy were associated with MCI. Only baseline depression was associated with dementia at follow-up. Total NPS at baseline was cross-sectionally associated with cognitive impairment in executive function, attention, and global cognition, but did not predict cognitive decline. Depression, anxiety, agitation, anxiety, and apathy were all associated...Continue Reading

Citations

Feb 13, 2013·Cardiovascular Psychiatry and Neurology·Lynn Reese KakosJohn Gunstad
May 24, 2014·The Australian and New Zealand Journal of Psychiatry·Henry BrodatyUNKNOWN PRIME study group
May 2, 2018·Journal of Alzheimer's Disease : JAD·M Clara SellesSergio T Ferreira
Jan 16, 2014·International Review of Psychiatry·Ruby S M TsangHenry Brodaty
Jun 13, 2014·International Journal of Geriatric Psychiatry·Elizabeta B Mukaetova-LadinskaRaj N Kalaria
Aug 15, 2019·Aging & Mental Health·Ilaria ParrottaUNKNOWN MAPT/DSA group
Dec 10, 2015·Current Opinion in Psychiatry·Linda MahAlexandra J Fiocco
Jun 1, 2017·Dementia and Neurocognitive Disorders·Yong Tae KwakMin-Seong Koo
Jan 4, 2018·International Journal of Geriatric Psychiatry·Ada Wai Tung FungLinda Chiu Wa Lam
Apr 10, 2015·Journal of Alzheimer's Disease : JAD·Catherine E MunroGad A Marshall
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Jeannie-Marie S LeoutsakosGwenn S Smith
Oct 14, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Isaac AcostaUNKNOWN 10/66 Dementia Research Group
Aug 16, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Saira Saeed MirzaHenning Tiemeier
Jul 1, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Krista L LanctôtEleenor H Abraham
Feb 23, 2019·Journal of Neural Transmission·Claus M EscherFrank Jessen
Mar 20, 2020·The Clinical Neuropsychologist·Wiltine G Moerman-van den BrinkRoy P C Kessels
Feb 15, 2018·Acta Psychiatrica Scandinavica·P VergerH Verdoux
May 28, 2020·International Psychogeriatrics·Hillary J RouseHuntington Potter
May 12, 2020·International Journal of Geriatric Psychiatry·Hillary J RouseHuntington Potter
Jul 22, 2018·JAMA Psychiatry·Jan Willem van DalenEdo Richard
May 28, 2019·Journal of Alzheimer's Disease : JAD·Simon DietlinBruno Vellas
Mar 3, 2020·Frontiers in Pharmacology·Wietse WielsSebastiaan Engelborghs
Oct 23, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·Janina Krell-RoeschYonas E Geda
Nov 20, 2020·International Journal of Psychiatry in Clinical Practice·Varvara ValotassiouJohn Papatriantafyllou
Feb 25, 2021·Journal of Gerontological Nursing·Logan Alison SweederNikki Hill
Mar 17, 2021·International Journal of Geriatric Psychiatry·Janina Krell-RoeschYonas E Geda
Mar 23, 2021·Journal of Alzheimer's Disease : JAD·Luciana Mascarenhas FonsecaNaomi Sage Chaytor
Mar 31, 2021·International Psychogeriatrics·Claudia K Suemoto, Cleusa P Ferri
May 11, 2021·International Psychogeriatrics·Yee-Lam E ChanChia-Fen Tsai
Jun 1, 2021·Frontiers in Neurology·Aline Maria M CiciliatiClaudia Kimie Suemoto
Jun 30, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V KurmyshevL V Bravve
Apr 15, 2020·Dementia and Geriatric Cognitive Disorders·Evangelia Martin, Latha Velayudhan

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