Neuropsychiatric syndromes in adults with intellectual disability: issues in assessment and treatment

Current Psychiatry Reports
Richard B FerrellThomas W McAllister

Abstract

The purpose of this article is to present a survey of important neuropsychiatric issues and recent findings regarding the evaluation and treatment of neuropsychiatric symptoms and syndromes in patients with intellectual disability (ID). The cause of ID, environmental or genetic, can be determined in few patients. Etiology is idiopathic in most patients. ID and psychiatric illness are not mutually exclusive; individuals with ID have increased rates of psychiatric illness. Although recognition of significant axis I psychopathology is important, not all challenging behaviors in persons with ID will have a clear axis I diagnosis. Psychologic, behavioral, and environmental treatments are appropriate measures, but pharmacotherapy often is needed. Our experience has shown us that the more severe, disruptive, and dangerous the behavior, the stronger the indication for empirical drug treatment trials. Community-based models of support with neuropsychiatric intervention can be a potent therapeutic combination in the management of challenging behaviors in individuals with ID.

References

Apr 1, 1990·The Journal of Pediatrics·C P TorfsS Cummins
Jul 1, 1989·Biological Psychiatry·P Glue
Oct 1, 1982·The American Journal of Psychiatry·L F Eaton, F J Menolascino
Feb 1, 1995·Journal of Intellectual Disability Research : JIDR·W Meins
May 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·A H Reid
May 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·J Jancar, I J Gunaratne
Dec 1, 1994·The American Journal of Psychiatry·B H KingV Ackerland
Jun 1, 1993·Journal of Intellectual Disability Research : JIDR·S Reiss, J Rojahn
Apr 1, 1993·Journal of Intellectual Disability Research : JIDR·N BourasC Drummond
Mar 1, 1996·Journal of the International Neuropsychological Society : JINS·M B Pulsifer
Apr 30, 1999·Journal of Intellectual Disability Research : JIDR·L Duggan, J Brylewski
Apr 30, 1999·Journal of Intellectual Disability Research : JIDR·S RaitasuoR K Salokangas
Jun 23, 1999·The Journal of ECT·M Thuppal, M Fink
Nov 5, 1999·Journal of Intellectual Disability Research : JIDR·M Vanstraelen, S P Tyrer
Nov 5, 1999·Journal of Intellectual Disability Research : JIDR·D J Clarke, G A Gomez
Feb 2, 2000·European Child & Adolescent Psychiatry·S L LinnaF Almqvist
Feb 25, 2000·Current Opinion in Oncology·A S PatelC A Griffin
May 17, 2000·American Journal of Medical Genetics·A S BassettR Weksberg
Jun 14, 2000·Journal of Medical Genetics·S J Knight, J Flint
Apr 12, 2001·Journal of Intellectual Disability Research : JIDR·J A Tsiouris
Jun 22, 2001·The Journal of ECT·M AzizR Tandon
Nov 16, 2001·Autism : the International Journal of Research and Practice·D W PerryA Roy
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·P Nokelainen, J Flint
Aug 3, 2002·The American Journal of Psychiatry·Michael G AmanUNKNOWN Risperidone Disruptive Behavior Study Group
Feb 1, 2003·Journal of Intellectual Disability Research : JIDR·J A TsiourisP Sturmey
Feb 1, 2003·Journal of Intellectual Disability Research : JIDR·N N CainL Deutsch
Feb 1, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jie Xu, Zhong Chen
Jun 17, 2003·Journal of Medical Genetics·B B A De VriesC van Ravenswaaij-Arts
Aug 1, 1964·The Journal of Pediatrics·D W SMITH, K E BOSTIAN
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Elisabeth M Dykens

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Citations

Jan 9, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Wai Lun Alan FungAnne S Bassett
Oct 9, 2016·Prenatal Diagnosis·Anne S BassettChristian R Marshall
May 20, 2018·American Journal of Medical Genetics. Part a·Nancy J ButcherAnne S Bassett
Nov 26, 2010·The American Journal of Nursing·Kathy H Baldridge, Frank Andrasik
Mar 15, 2020·Child and Adolescent Psychiatric Clinics of North America·Cory ShulmanAmy Esler
Aug 19, 2021·BMJ Case Reports·Olga SchmahlRadboud Marijnissen

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