Neuropsychological abnormalities in children with the Panayiotopoulos syndrome point to parietal lobe dysfunction

Epilepsy & Behavior : E&B
Ricardo LopesAlberto J R Leal

Abstract

Panayiotopoulos syndrome (PS) is a common epilepsy syndrome associated with rare clinical seizures and unknown localization of the epileptogenic area. Despite findings of normal development in patients with PS, recent neuropsychological studies point to subtle and diverse cognitive impairments. No well-outlined hypothesis about the localization of the brain dysfunction responsible for these impairments has been proposed. We further explored the cognitive dysfunctions in PS and made inferences on the most likely anatomical localization of brain impairment. A group of 19 patients (aged 6-12) with PS was rated according to spike activity and lateralization. The patients were submitted to a neuropsychological evaluation to assess general intelligence, memory, language, visual-perceptual abilities, attention, and executive functions. Using 35-channel scalp EEG recordings, the N170 face-evoked event-related potential (ERP) was obtained to assess the functional integrity of the ventral pathway. All patients with PS showed normal IQ but subtle and consistent neurocognitive impairments. Namely, we found abnormalities in the copy task of the Rey-Osterrieth Complex Figure and in the Narrative Memory Test. There was no correlation between ...Continue Reading

References

Nov 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·C P Panayiotopoulos
Apr 11, 2000·Epilepsia·S GülgönenB D Townes
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Nov 29, 2005·Brain & Development·Kiyoko WatanabeYoko Ohtsuka
Apr 3, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alberto J R LealEulália Calado
Jul 16, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alberto J R LealEulália Calado
Aug 30, 2008·Brain & Development·Tatsuya OginoYoko Ohtuska
Jan 14, 2010·Epilepsia·Paola De RoseEugenio Mercuri
Mar 2, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vasileios KokkinosChrysostomos P Panayiotopoulos
Jul 27, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alberto J R LealJosé C Ferreira

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Citations

Dec 29, 2015·Epilepsy & Behavior : E&B·Samantha L HodgesM Scott Perry
Nov 19, 2014·Sleep & Breathing = Schlaf & Atmung·Maria GogouEvaggelos Pavlou
May 26, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Octávio MouraMário R Simões
Jul 2, 2020·Developmental Medicine and Child Neurology·Eric L A Fonseca WaldJos G M Hendriksen
Oct 16, 2018·Frontiers in Pharmacology·Jaya KumarSrijit Das
Dec 2, 2020·Epilepsy & Behavior : E&B·Katharine Bailey, Nancie Im-Bolter
Jan 26, 2021·Epilepsy & Behavior : E&B·Gian Marco DumaGiovanni Mento
Apr 6, 2021·Brain and Language·Katharine BaileyNancie Im-Bolter

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